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International Journal of Dermatology, 1992
Toxic epidermal necrolysis is a severe mucocutaneous reaction pattern characterized by fever, systemic toxicity, tenderness, erythema, and widespread exfoliation. Lyell1 of Glasgow, Scotland, and Lang and Walker2 of Cape Town, South Africa, independently described this syndrome in 1956.
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Toxic epidermal necrolysis is a severe mucocutaneous reaction pattern characterized by fever, systemic toxicity, tenderness, erythema, and widespread exfoliation. Lyell1 of Glasgow, Scotland, and Lang and Walker2 of Cape Town, South Africa, independently described this syndrome in 1956.
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Plasmapheresis in toxic epidermal necrolysis
International Journal of Dermatology, 1997Abstract Background The treatment of toxic epidermal necrolysis (TEN) is usually based on the removal of the offending drug(s), fluid replacement, nutritional support, and local management. The mortality and morbidity, however, remain high and the death rate may be reduced to 10% only in special centers that use biologic dressings. Plasma exchange (PE)
G C, Chaidemenos +5 more
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Current Opinion in Allergy & Clinical Immunology, 2013
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening severe adverse drug reactions. Once thought to be idiosyncratic and unpredictable, there has been significant progress made in the understanding of the pathomechanism and pharmacogenetics of such reactions.
Haur-Yueh, Lee, Wen-Hung, Chung
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Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening severe adverse drug reactions. Once thought to be idiosyncratic and unpredictable, there has been significant progress made in the understanding of the pathomechanism and pharmacogenetics of such reactions.
Haur-Yueh, Lee, Wen-Hung, Chung
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The Lancet, 1998
1coined the term necrolysis to describe four clinical cases characterised pathologically by necrosis of the epidermis, and clinically by widespread epidermolysis—a loosening of the epidermis leading to blister formation, exfoliation, or both. Large sheets of skin had peeled off, leaving a raw, denuded base.
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1coined the term necrolysis to describe four clinical cases characterised pathologically by necrosis of the epidermis, and clinically by widespread epidermolysis—a loosening of the epidermis leading to blister formation, exfoliation, or both. Large sheets of skin had peeled off, leaving a raw, denuded base.
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Intestinal toxic epidermal necrolysis
Gazzetta Medica Italiana Archivio per le Scienze Mediche, 2018Toxic epidermal necrolysis (TEN), also known as the Stevens-Johnson Syndrome (SJS), is defined as severe, lifethreatening mucocutaneous reactions, predominantly drug induced, but also associated with infectious diseases. Clinical manifestations consist of erythematous cutaneous lesions, with blister formation and epidermal detachment as a consequence ...
Cudia, Antonella +4 more
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Management of toxic epidermal necrolysis
Hospital Medicine, 2000Toxic epidermal necrolysis and Stevens–Johnson syndrome are rare, life-threatening drug reactions. Widespread epidermal necrosis and mucosal erosions lead to complications similar to those developing after extensive burns. Treatment is supportive. The role of steroids and other potential disease-modifying agents remains to be established by controlled ...
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Advances in toxic epidermal necrolysis
Seminars in Cutaneous Medicine and Surgery, 1996On the basis of the clinicopathologic and causative characteristics, one can separate an erythema multiformis spectrum from a toxic epidermal necrolysis (TEN)-Stevens Johnson syndrome which is a drug induced disease. Despite a well-known clinical aspect, several cutaneous diseases may be mistaken for TEN.
J E, Revuz, J C, Roujeau
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The management of toxic epidermal necrolysis
Australasian Journal of Dermatology, 2012ABSTRACTThe mortality rate of Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) is high; approximately 5% for SJS and 25% for TEN. It is therefore vital for the treating physician to recognise SJS and TEN promptly through the identification of these diseases' characteristic clinical features so that the offending drug is promptly ...
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Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis: A Review of Diagnosis and Management
Medicina (Lithuania), 2021Kiran Motaparthi, Simo Huang
exaly
A Review of the Systemic Treatment of Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis
Biomedicines, 2022Hua-Ching Chang +2 more
exaly