Results 81 to 90 of about 3,261,943 (303)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Toxic arbitrage [PDF]

, 2017
Short-lived arbitrage opportunities arise when prices adjust with a lag to new information. They are toxic because they expose dealers to the risk of trading at stale quotes.
Foucault, Thierry, Kozhan, Roman, Tham, Wing Wah   +2 more
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Morphological and Metabolite Responses of Potatoes under Various Phosphorus Levels and Their Amelioration by Plant Growth-Promoting Rhizobacteria

, 2021
Low phosphorus (P) availability is a major limiting factor for potatoes. P fertilizer is applied to enhance P availability; however, it may become toxic when plants accumulate at high concentrations.
Elke Pawelzik, Dominik Schneider, Rolf Daniel, Leangsrun Chea, Marcel Naumann, Birgit Pfeiffer, Pfeiffer, Birgit; Department of Genomic and Applied Microbiology, Institute of Microbiology and Genetics, University of Göttingen, Grisebachstraße 8, 37077 Göttingen, Germany, bpfeiff@gwdg.de, Daniel, Rolf, Naumann, Marcel, Pawelzik, Elke; Department of Crop Sciences, Division Quality of Plant Products, University of Göttingen, Carl-Sprengel-Weg 1, 37075 Göttingen, Germany, epawelz@gwdg.de, Chea, Leangsrun; Department of Crop Sciences, Division Quality of Plant Products, University of Göttingen, Carl-Sprengel-Weg 1, 37075 Göttingen, Germany, leangsrun.chea@agr.uni-goettingen.de, Pawelzik, Elke, Pfeiffer, Birgit, Naumann, Marcel; Department of Crop Sciences, Division Quality of Plant Products, University of Göttingen, Carl-Sprengel-Weg 1, 37075 Göttingen, Germany, marcel.naumann@agr.uni-goettingen.de, Schneider, Dominik, Chea, Leangsrun, Schneider, Dominik; Department of Genomic and Applied Microbiology, Institute of Microbiology and Genetics, University of Göttingen, Grisebachstraße 8, 37077 Göttingen, Germany, dschnei1@gwdg.de, Daniel, Rolf; Department of Genomic and Applied Microbiology, Institute of Microbiology and Genetics, University of Göttingen, Grisebachstraße 8, 37077 Göttingen, Germany, rdaniel@gwdg.de   +17 more
core   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

EFFECT OF TOXIC HEAVY METALS AT DOWNSTREAM IRRIGATION OF WASTEWATER TREATMENT PLANT

, 2023
For several years, domestic wastewater from Addis Ababa's seven sub-cities has been treated at Kality domestic wastewater treatment plant. Despite being designed to treat domestic waste, certain industrial wastes were discharged into the treatment plant ...
Girma, Johnny, Kemal, Asie, Nigussie, Agizew   +2 more
core   +1 more source

Haploidentical Hematopoietic Cell Transplantation for Infants With X‐Linked Severe Combined Immunodeficiency Using Post‐Transplant Cyclophosphamide

Pediatric Blood &Cancer, EarlyView.
Shuhei Takahashi, Akito Kawachi, Dan Tomomasa, Eri Watanabe, Yuji Fujita, Yuya Sato, Masahiro Sekiguchi, Kentaro Watanabe, Moe Hidaka, Akihiro Hoshino, Takahiro Kamiya, Masatoshi Takagi, Hirokazu Kanegane, Motohiro Kato   +13 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Potential for identifying plant-based toxins on San hunter-gatherer arrowheads

South African Journal of Science, 2017
The antiquity of the use of hunting poisons has received much attention in recent years. In this paper we present the results of a pilot study designed to detect the presence of organic compounds, typically of less than 1200 Da, from poisonous plants ...
Madelien Wooding, Justin Bradfield, Vinesh Maharaj, Dwayne Koot, Lyn Wadley, Linda Prinsloo, Marlize Lombard   +6 more
doaj   +1 more source