Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Environment InternationalPer- and polyfluoroalkyl substances (PFAS) are widely used in industry and have been linked to various adverse health effects. Communities adjacent to sites where PFAS are manufactured, stored, or used may be at elevated risk.
Jeffrey M. Minucci +7 more
doaj +1 more source
Potentially Toxic Substances and Associated Risks in Soils Affected by Wildfires: A Review. [PDF]
Toxics, 2022 Fernandez-Marcos ML.
europepmc +1 more source
Trouble in Toyland: The 23rd Annual Toy Safety Survey [PDF]
, 2008 Details findings on deaths and injuries from and toxic chemicals in toys, with a focus on lead and phthalates. Includes tips for consumers and recommendations for policy makers and the Consumer Product Safety Commission.
Edmund Mierzwinski, Liz Hitchcock
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Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Background of Toxic-Substances-Induced Morphological Alterations in the Umbilical Cord Vessels and Fetal Red Blood Cells. [PDF]
Int J Mol Sci, 2022 Zahorán S +7 more
europepmc +1 more source
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
Metal-Induced Genotoxic Events: Possible Distinction Between Sporadic and Familial ALS
ToxicsMetal exposure is a potential risk factor for amyotrophic lateral sclerosis (ALS). Increasing evidence suggests that elevated levels of DNA damage are present in both familial (fALS) and sporadic (sALS) forms of ALS, characterized by the selective loss ...
William Wu Kim +9 more
doaj +1 more source
Analysis of dermal exposure assessment in the US Environmental Protection Agency Toxic Substances Control Act risk evaluations of chemical manufacturing. [PDF]
Toxicol Ind Health, 2023 Lynch HN +5 more
europepmc +1 more source
Industrial Sources of Dioxin Poisoning in Mossville, Louisiana: A Report Based on the Government's Own Data [PDF]
, 2007 Since 1998, the U.S. Agency for Toxic Substances and Disease Registry (ATSDR) -- which is a division of the Centers for Disease Control -- has conducted an Exposure Investigation of dioxins in Mossville, Louisiana, an historic African American community ...
Wilma Subra
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