Results 61 to 70 of about 5,570 (218)

Finding inhabited settlements and tracking vaccination progress: the application of satellite imagery analysis to guide the immunization response to confirmation of previously-undetected, ongoing endemic wild poliovirus transmission in Borno State, Nigeria

International Journal of Health Geographics, 2019
Background Four wild polio-virus cases were reported in Borno State, Nigeria 2016, 1 year after Nigeria had been removed from the list of polio endemic countries by the World Health Organization.
Jeff Higgins, Usman Adamu, Kehinde Adewara, Adeshina Aladeshawe, Aron Aregay, Inuwa Barau, Andrew Berens, Omotayo Bolu, Nina Dutton, Nnaemeka Iduma, Bryant Jones, Brian Kaplan, Sule Meleh, Melton Musa, Gatei wa Nganda, Vincent Seaman, Anupma Sud, Stephane Vouillamoz, Eric Wiesen   +18 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Progress on internal exposure to typical environmental persistent organic pollutants and cancer

环境与职业医学
Environmental pollution is closely linked to the occurrence and development of cancer. Chemical carcinogens are the most important environmental factors causing cancer in humans. Among them, persistent organic pollutants (POPs) are characterized by their
Xuerui MA, Wanjing TONG, Yijia ZHANG, Wenjuan ZHANG, Yong LIANG, Maoyong SONG   +5 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Bisphenol M exposure promotes adiposity in mice via disrupting hepatic metabolism and gut microbiota homeostasis

Ecotoxicology and Environmental Safety
Bisphenol M (BPM), a structural analog of bisphenol A (BPA) commonly used in food packaging and consumer plastics, remains incompletely characterized in terms of its obesogenic potential and underlying molecular mechanisms, posing challenges for evidence-
Xin Wang, Jie Zhao, Zehong Wu, Ling Wang, Wenjuan Zhang, Jie Zhang, Yong Liang   +6 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Light intensity can significantly regulate cadmium transformation into CdS nanoparticles in microalgae (Dunaliella salina and Phaeodactylum tricornutum)

Ecotoxicology and Environmental Safety
Light is a critical factor influencing algal growth and contributes to the uptake of metal elements by algae. However, the impact of light on the bioavailability and transformation of heavy metals requires further exploration, particularly in the context
Chang Shi, Zesheng Yuan, Xin Zhong, Qingqing Yang, Yongguang Yin, Ligang Hu, Yun Wang, Yong Liang   +7 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Heavy metals in reservoirs: pollution characteristics, remediation technologies, and future prospects

Agricultural Ecology and Environment
Reservoir ecosystems play a critical role in water resource management and socio-economic development, yet they are increasingly threatened by heavy metal (HM) contamination, highlighting the urgent need for interdisciplinary collaboration and innovative
Song Cui, Chao Ma, Fuxiang Zhang, Zhaoyang Jia, Fengyang Pan, Dingwen Zhang, Hongliang Jia, Jingwei Wang, Zulin Zhang, Rupert Hough   +9 more
doaj   +1 more source