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Toxicological profile for aldrin and dieldrin [PDF]

VERSION HISTORYDate DescriptionJune 2022 Final toxicological profile releasedJuly 2021 Draft for public comment toxicological profile releasedSeptember 2002 Final toxicological profile releasedApril 1993 Final toxicological profile ...

core  

TOXICOLOGICAL ANALYSIS OF HAIR IN FORENSIC TOXICOLOGY: APPLICATIONS, LIMITATIONS, AND CLINICAL AND EXPERT PERSPECTIVES

Hair toxicological analysis has become an important tool in clinical and forensic toxicology due to its ability to detect long-term exposure to drugs of abuse, medications, and other chemical substances.
Sara Luciana de Andrade
core   +1 more source

Plaque‐Hepatic Targeting Nanotherapy Disrupts the PCSK9‐LOX‐1 Axis to Suppress oxLDL in Atherosclerosis

Advanced Science, EarlyView.
Self‑amplifying PCSK9–LOX‑1 feedback axis drives atherosclerotic progression by promoting oxLDL generation and endothelial uptake. A dual‑targeting nanoplatform (siPCSK9@PEAL NPs‑aL) is constructed to simultaneously silence hepatic PCSK9 for lipid lowering and block plaque LOX‑1 for anti‑inflammation.
Yi Duan, Yijie Qiu, Yan Zhu, Quan Wang, Jiangtao Lin, Yourong Duan, Qi Wang, Yi Dong   +7 more
wiley   +1 more source

When herbal supplements cause heart problems: Clinical case report and forensic toxicological analysis. [PDF]

Toxicol Rep
Theuer T, Faber K, Oberli L, Schweingruber T, Fraiture MA, Roosens N, Kindler A, Rudiger A, Leist R, Vanhee C.   +9 more
europepmc   +1 more source

The Interest of a Systematic Toxicological Analysis Combined with Forensic Advice to Improve the Judicial Investigation and Final Judgment in Drug Facilitated Sexual Assault Cases. [PDF]

Pharmaceuticals (Basel), 2021
Wille SMR, Van Dijck K, Van Assche A, Di Fazio V, Ramiréz-Fernandéz MDM, Vanvooren V, Samyn N.   +6 more
europepmc   +1 more source

Nucleoside‐Modified mRNA Encoding Alpha‐Galactosidase A Ameliorates Fabry Disease Phenotypes in Human IPSC‐Derived Cardiomyocytes

Advanced Science, EarlyView.
Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem, Lea Oehlsen, Sedef Ersoy, Jia Li Ye, Natalie Weber, Elisa Mohr, Wilson Agyapong, Junqing Liu, Maximilian Fuchs, Ke Xiao, Christopher Jahn, Reto Eggenschwiler, Tobias Cantz, Julia Beimdiek, Falk F. R. Buettner, Theresia Kraft, Jan Hegermann, Ivonne J. Knorr, Lisa Ernst, Linda Feldbrügge, Resa Puffert, Kevin Schmidt, Christian Bär, Jeannine Hoepfner, Thomas Thum   +24 more
wiley   +1 more source

Toxicological analysis of metabolites in ischemic stroke based on salivary metabolomics. [PDF]

Front Mol Biosci
Liu YS, Long YY, Liu J, Liu YC, Zhang S, Xu YJ, Fu SY, Li H, Liu WH.   +8 more
europepmc   +1 more source

Deep Learning‐Driven Discovery and Engineering of an Efficient PETase for Depolymerization and Detoxification of PET Microplastics Under Physiological Conditions

Advanced Science, EarlyView.
A deep learning–driven pipeline mining 246 million protein sequences uncovers AhPETase, an evolutionarily distinct PET hydrolase. Engineered variant AhPETaseM1 degrades post‐consumer PET microplastics under physiological conditions and reverses microplasticinduced cytotoxicity in human lung and colon cells, establishing enzymatic microplastic ...
Yuxuan Wang, Shijie He, Yuheng Chang, Sheng Mao, Jianan Canal Li, Binbin Chen, Hongxun Gao, Mingchun Xu, Chenxu Liu, Yajie Wang   +9 more
wiley   +1 more source

WCN24-1245 KIDNEY INJURY IN SNAKEBITE PATIENTES WHIT AND WHITOUT SPOONTANEOUS BLEEDING AND IMPLICATIONS OF ANTIVENOM THERAPY

Kidney International Reports
Nicole Coelho Lopes, Gdayllon Cavalcante Meneses, Amanda Medeiros Fernandes, Victória Danielly Rabelo Almeida, Letícia Machado de Araújo, Bruna Viana Barroso Martins, Poliana Lemos Moura Moreira Albuquerque, Elizabeth De Francesco Daher, Alice Maria Costa Martins   +8 more
doaj   +1 more source

Viscera Preservation in Medical Board Autopsies: Timelines, Outcomes, and Systemic Inefficiencies in Toxicological Analysis. [PDF]

Cureus
Kumar A, Chaudhary A, Bhagat AK, Shubhendu K, Mundri S.   +4 more
europepmc   +1 more source