Trinuclear Heptamethine Dyes for Shortwave Infrared In Vivo Imaging
Angewandte Chemie, EarlyView.The reactivity of cyclopentenyl‐bridged polymethine dyes is leveraged to synthesize shortwave infrared (SWIR)‐emissive di‐ and trinuclear polymethine dyes. Chromenylium‐ and flavylium‐based trinuclear dyes demonstrate increased nucleophilic stability, minimal aggregation in micelle formulations, and notable lymph node accumulation.
Cesar A. Garcia +6 more
wiley +2 more sources
Intoxications and knowledge about toxicological information centers in undergraduate students in the state of Jalisco, Mexico. [PDF]
Aten PrimariaRojas-Prado E +3 more
europepmc +1 more source
Australian Journal of Social Issues, EarlyView.ABSTRACT Alcohol and other drug‐facilitated sexual violence can have significant impacts on victim‐survivors, yet little is known about what support service providers offer them. To understand the experiences and perceptions of service providers, interviews with counsellors, health workers, forensic toxicologists and harm reduction workers were ...
Jessica Ison +5 more
wiley +1 more source
Mechanistic insights into triclosan-induced hepatotoxicity: A network toxicology and molecular docking approach. [PDF]
PLoS OneLiu F +7 more
europepmc +1 more source
Metabolic and biochemical profiling reveals phenotypic heterogeneity in Zucker diabetic fatty rats
Animal Models and Experimental Medicine, EarlyView.Genetically uniform Zucker Diabetic Fatty (ZDF) rats spontaneously develop four distinct metabolic phenotypes despite identical housing and diet conditions. Each phenotype exhibits unique biomarker signatures encompassing glucose homeostasis, insulin secretion, polyol pathway activation, oxidative stress, inflammatory cytokines, and neurotrophic ...
Marek Lepáček +3 more
wiley +1 more source
Advanced NanoBiomed Research, EarlyView.Despite significant advances, most academic research fails to result in medical products that benefit patients. This guide shares five key steps to help researchers close that gap: set clear goals, test thoroughly, protect ideas, build diverse teams, and partner with industry.
Cristina Oldani +4 more
wiley +1 more source
Correction: Identification of small GTPases as potential target proteins of the mycotoxin and renal carcinogen ochratoxin A. [PDF]
Arch ToxicolBorchers J +7 more
europepmc +1 more source
Beyond PEGylation: Archaeal Lipids for Long‐Circulating Liposomes
Advanced NanoBiomed Research, EarlyView.Archaeal lipid‐based liposomes, particularly those containing caldarchaeol (GDGT), were found to significantly prolong the circulation time of vancomycin in rats, matching the pharmacokinetic properties of PEGylated systems. These findings suggest archaeal lipids as promising non‐PEG excipients for parenteral applications to minimize drug clearance ...
Viktor Sedlmayr +9 more
wiley +1 more source
Corrigendum to "Prevention of colitis-induced liver oxidative stress and inflammation in a transgenic mouse model with increased omega-3 polyunsaturated fatty acids" [Redox Biol. 64 (2023) 102803]. [PDF]
Redox BiolRohwer N +11 more
europepmc +1 more source
Analysis &Sensing, EarlyView.Electrospray ionization mass spectrometry (ESI‐MS) combined with thermodynamic modeling provides the first direct characterization of radium speciation in synthetic gastrointestinal biofluids. Free Ra2+ ions predominate with minimal protein binding and negligible EDTA complexation. Crown ethers enable effective Ra complexation.
Linus Holtmann +5 more
wiley +1 more source