Results 151 to 160 of about 820,187 (404)
Medical Materials and Device Innovation: Choosing the Right and Relevant Biological Models
Advanced Therapeutics, EarlyView.Choosing the right disease model is key to safe, effective medical innovation. When models reflect human biology and clinical needs, they improve translation, reduce risk, and accelerate progress. Advances in 3D tissues, organ‐on‐chip, and humanized systems offer exciting opportunities. With thoughtful selection and clinician input, biomedical research
Inge K. Herrmann +1 more
wiley +1 more source
Optimal designs for dose finding experiments in toxicity studies [PDF]
We construct optimal designs for estimating fetal malformation rate, prenatal death rate and an overall toxicity index in a toxicology study under a broad range of model assumptions.
Dette, Holger +2 more
core
Advanced Therapeutics, EarlyView.The graphical abstract illustrates the combined effect of PTT and PDT using metal‐organic frameworks (MOFs) in a cancer treatment model. Tumor‐bearing mice are irradiated with different laser lights, which activate the MOF nanoparticles within cancer cells. The MOFs produce reactive oxygen species through PDT, while PTT elevates the temperature to kill
Kayalvizhi Samuvel Muthiah +5 more
wiley +1 more source
XXV.—The detection of traces of mercury salts for toxicological purposes [PDF]
, 1917 Kendall Colin Browning
openalex +1 more source
AAOHN Journal, 1986 With the discovery of new “toxins.” the onus is not only on the manufacturer but also on the user This means fully evaluating the health and safety effects of the substances produced and used As health care professionals, we must continue to increase our knowledge and skills In order to maintain a healthy and safe work environment. The role of OHNs in
openaire +3 more sources
Rewiring Neuroimmunity: Nanoplatform Innovations for CNS Disease Therapy
Advanced Therapeutics, EarlyView.This review explores emerging nanoplatform strategies designed to modulate neuroimmune responses for treating central nervous system (CNS) disorders. It examines structural and microenvironmental barriers, advances in multifunctional and targeted nanotechnologies, and highlights clinical progress and translational challenges, offering insights into the
Muhammad Usman Akbar +7 more
wiley +1 more source
Evolution of Ocular Organ‐On‐Chip Systems for Disease Modelling and Drug Testing: Where are We Now?
Advanced Therapeutics, EarlyView.The rise in ophthalmic diseases due to aging, screen use, and environmental factors has driven demand for better ocular models. Traditional systems fall short, encouraging the development of organ‐on‐chip devices. These microfluidic platforms replicate eye tissue architecture, enable drug screening, and simulate ocular diseases.
Sara Trujillo
wiley +1 more source
Toxicological effects of izal on the dog and cat [PDF]
, 1900 Frederick Hobday
openalex +1 more source
LRRC8A Regulates Outer Hair Cell Volume and Electromotility and is Required for Hearing
Advanced Science, EarlyView.This study identifies LRRC8A‐dependent volume‐regulated anion channels (VRACs) as essential for cochlear outer hair cells' electromotility and auditory signal amplification. LRRC8A deficiency disrupts cell volume control, impairs auditory sensitivity, and causes deafness, while targeted LRRC8A re‐expression restores auditory function.
Shengnan Wang +15 more
wiley +1 more source