Results 191 to 200 of about 791,172 (411)

Radiation Exposure Induced Blood–Brain Barrier Injury via Mitochondria‐Mediated Sterile Inflammation

open access: yesAdvanced Science, EarlyView.
This work describes a blood–brain barrier (BBB) microphysiological system (MPS) to explore the responses of BBB to radiation exposure. Following radiation exposure, obvious BBB comprise and brain endothelial injuries are detected. Mechanism study shows radiation induced significant sterile inflammation via mitochondrial dysfunction and cGAS‐STING ...
Peng Wang   +6 more
wiley   +1 more source

Meaningful Toxicology [PDF]

open access: yes, 1973
The scope of toxicology, therefore, may extend from the study of a single element such as lead to a complex, chemically uncharacterized substance such as snake venom; from an overdose of heroin to the effects of long-term exposure to low levels of ...
Blanke, Robert V.
core   +1 more source

Single cell gel/comet assay: Guidelines for in vitro and in vivo genetic toxicology testing

open access: yesEnvironmental and Molecular Mutagenesis, 2000
R. Tice   +9 more
semanticscholar   +1 more source

EFTUD2 Regulates Cortical Morphogenesis via Modulation of Caspase‐3 and Aifm1 Splicing Pathways

open access: yesAdvanced Science, EarlyView.
EFTUD2, a spliceosomal GTPase linked to MFDM, regulates cortical development through apoptotic control. Conditional Eftud2 knockout in murine neural stem cells induces microcephaly and cortical disorganization, while pathogenic variants drive neuronal loss.
Liping Chen   +12 more
wiley   +1 more source

Fire toxicology program. JSC methodology [PDF]

open access: yes
Toxicological testing of spacecraft materials was initiated in 1965. Toxicological evaluations of the pyrolysis/combustion products of candidate spacecraft materials were performed using a modified 142 liter Bethlehem Chamber equipped with a Linberg ...
Bafus, D., Schneider, H.
core   +1 more source

Trypstatin as a Novel TMPRSS2 Inhibitor with Broad‐Spectrum Efficacy against Corona and Influenza Viruses

open access: yesAdvanced Science, EarlyView.
Trypstatin, a 61‐amino acid Kunitz‐type protease inhibitor derived from human Bikunin, potently inhibits TMPRSS2 and related proteases. It blocks spike‐ and hemagglutinin‐mediated entry of multiple respiratory viruses in vitro reduces SARS‐CoV‐2 replication in human airway cultures, and lowers viral load and symptoms in infected hamsters, demonstrating
Jan Lawrenz   +24 more
wiley   +1 more source

Are PM6:Y6 Bulk Heterojunction Photoactive Films Cytocompatible and Electrically Stable in Biological Environments?

open access: yesAdvanced Electronic Materials, EarlyView.
PM6:Y6 organic photovoltaic films are systematically studied to understand their potential for use in bioelectronics. The films exhibit excellent stability in simulated physiological environments, enabling consistent power delivery and demonstrating compatibility with rat neurons and the choriallantoic membrane of chicken embryos.
Mathias Polz   +10 more
wiley   +1 more source

Advances in the Use of Mass Spectral Libraries for Forensic Toxicology [PDF]

open access: yes, 2017
Gas chromatography in combination with mass spectrometry (GC-MS) plays an important role in the field of analytical toxicology. The identification of unknown compounds is very frequently undertaken with GC-MS and utilizing mass spectral libraries ...
Aebi, Beat, Bernhard, Werner
core  

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