Results 191 to 200 of about 706,933 (359)

Mapping physiology: A systems biology approach for the development of alternative methods in toxicology

Bernard Staumont, Luiz Carlos Maia Ladeira, A. Gamba, Harm J. Heusinkveld, Aldert H. Piersma, Ellen Fritsche, Rosalinde Masereeuw, Tamara Vanhaecke, Marc Teunis, T. Luechtefeld, Thomas Härtung, Ramiro Jover, Mathieu Vinken, Liesbet Geris   +13 more
openalex   +1 more source

PTG‐Dependent Glycogen Metabolic Dysfunction Drives Impaired Adipose Browning: A Novel Mechanism Linking PM2.5 to Metabolic Disorders

Advanced Science, EarlyView.
This study provides the first evidence that PM2.5 impairs iWAT browning via PTG‐mediated glycogen metabolism disruption, which is initiated by ADRB3 inhibition and subsequently triggers VEGFB upregulation. It thereby delineates the ADRB3‐PTG‐VEGFB axis as central to PM2.5‐induced metabolic dysfunction and identifies adipose glycogen metabolism as a ...
Limin Wang, Renjie Hu, Yanxi Chai, Ping He, Sanduo Li, Lisha Zhao, Wenbin Zhao, Lu Zhang, Li Qin, Ran Li, Xiaoli Hou, Qinghua Sun, Cuiqing Liu   +12 more
wiley   +1 more source

Dipiperazine‐Phenyl Derivatives Based on Convergent Molecular Platforms Can Reverse Multidrug Resistance in Gram‐Negative Bacteria by Inhibiting Efflux and Permeabilizing Cell Membranes

Advanced Science, EarlyView.
By integrating a convergent molecular platform strategy, this study designed a novel dual‐target C5 to combat multidrug‐resistant Gram‐negative bacteria. C5 synergistically enhances antibiotic efficacy by inhibiting efflux pumps and increasing bacterial membrane permeability.
Jiale Dong, Ting Guo, Yi Huang, Yangchun Ma, Weijin Chen, Jie Xue, Jun Jiang, Enhui Dong, Yue Kong, Hang Ding, Wenlong Zhang, Shutao Ma   +11 more
wiley   +1 more source

Upper Respiratory Tract Lesions in Inhalation Toxicology [PDF]

, 2007
Roger A. Renne, Kathy M. Gideon, Sam J. Harbo, Laurie M. Staska, Sondra L. Grumbein   +4 more
openalex   +1 more source

Immunomodulatory Hydrogel Coating with SeNPs and Lithium Silicate Synergistically Promotes Osseointegration and Prevents Infection on Titanium Implants

Advanced Science, EarlyView.
This study introduces a multifunctional hydrogel coating (Lap‐CMCSMA/GelMA@SeNPs) that scavenges ROS, modulates immune responses, and shows strong antibacterial activity. It effectively restores the peri‐implant microenvironment. The coating exhibits excellent biocompatibility and promotes osteogenic differentiation.
Su Jiang, Baisheng Cai, Cong Ye, Kefan Wu, Kuan Liu, Pengcheng Xu, Fan Liu, Yake Liu   +7 more
wiley   +1 more source

Correction: Licochalcone D reduces H₂O₂-induced SH-SY5Y cell neurotoxicity by regulating reactive oxygen species. [PDF]

Front Pharmacol
Kwak AW, Park S, Oh HN, Shim JH, Yoon G, Kim WK.   +5 more
europepmc   +1 more source

Binding Properties of Chemical Substances to the Estrogen Receptor(PROCEEDINGS OF 24TH SYMPOSIUM ON TOXICOLOGY AND ENVIRONMENTAL HEALTH)

, 1999
Makoto Nakai, Yukiko Tabira, Yoshikuni Yakabe, Etsuko Tsukamoto, Yasuyuki Shimohigashi, Mineo Takatsuki   +5 more
openalex   +2 more sources

Biological and electrochemical treatments of coal mine-impacted water (MIW): toxicological evaluation on the duckweed Landoltia punctata

, 2022
Caroline Rodrigues, Cristina Moreira Lalau, Dámaris Núñez-Gómez, Rodrigo Costa Puerari, Hioná V.D.M. Follmann, Bianca Vicente Costa Oscar, Flávio Rubéns Lapolli, William Gerson Matias, María Ángeles Lobo-Recio   +8 more
openalex   +1 more source

Learned Conformational Space and Pharmacophore Into Molecular Foundational Model

Advanced Science, EarlyView.
The Ouroboros model introduces two orthogonal modules within a unified framework that independently learn molecular representations and generate chemical structures. This design enables flexible optimization strategies for each module and faithful structure reconstruction without prompts or noise.
Lin Wang, Yifan Wu, Hao Luo, Minglong Liang, Yihang Zhou, Cheng Chen, Chris Liu, Jun Zhang, Yang Zhang   +8 more
wiley   +1 more source

Navigating the AI Frontier in Toxicology: Trends, Trust, and Transformation. [PDF]

Curr Environ Health Rep
Luechtefeld T, Hartung T.
europepmc   +1 more source