Results 71 to 80 of about 78,599 (247)

Transgenic selection and underlying mechanisms in apicomplexan parasites

The FEBS Journal, EarlyView.
Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju, Rakhee Lohia, Nishith Gupta   +2 more
wiley   +1 more source

Toxoplasma gondii infection drives conversion of NK cells into ILC1-like cells

eLife, 2019
Innate lymphoid cells (ILCs) were originally classified based on their cytokine profiles, placing natural killer (NK) cells and ILC1s together, but recent studies support their separation into different lineages at steady-state.
Eugene Park, Swapneel Patel, Qiuling Wang, Prabhakar Andhey, Konstantin Zaitsev, Sophia Porter, Maxwell Hershey, Michael Bern, Beatrice Plougastel-Douglas, Patrick Collins, Marco Colonna, Kenneth M Murphy, Eugene Oltz, Maxim Artyomov, L David Sibley, Wayne M Yokoyama   +15 more
doaj   +1 more source

Tissue Resident Memory Cells: Friend or Foe?

Immunology, EarlyView.
Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude, Jude E. Uzonna, Janilyn Arsenio   +2 more
wiley   +1 more source

Hiding inside the host: development and application of "Neospora caninum" bradyzoite in vitro culture [PDF]

, 2003
The bradyzoite stage of the apicomplexan parasite Neospora caninum represents a hypobiotic, slowly proliferating and tissue cyst forming stage, which can survive in the immunocompetent host for several years. Tissue cysts are orally infectious.
Vonlaufen, Nathalie
core   +1 more source

Secuelas clínicas y neurodesarrollo de pacientes pediátricos con toxoplasmosis congénita en un centro de cuarto nivel

Biomédica: revista del Instituto Nacional de Salud
Introducción. La toxoplasmosis congénita es una enfermedad parasitaria de importante prevalencia a nivel mundial, con gran morbilidad y afectación del neurodesarrollo en pacientes pediátricos. Objetivo. Describir las secuelas y valorar el neurodesarrollo
Sebastián Posada-Bustos, Ana Cristina Mariño, Eugenia Espinosa-García   +2 more
doaj   +1 more source

Profiling of myristoylation in Toxoplasma gondii reveals an N-myristoylated protein important for host cell penetration

eLife, 2020
N-myristoylation is a ubiquitous class of protein lipidation across eukaryotes and N-myristoyl transferase (NMT) has been proposed as an attractive drug target in several pathogens.
Malgorzata Broncel, Caia Dominicus, Luis Vigetti, Stephanie D Nofal, Edward J Bartlett, Bastien Touquet, Alex Hunt, Bethan A Wallbank, Stefania Federico, Stephen Matthews, Joanna C Young, Edward W Tate, Isabelle Tardieux, Moritz Treeck   +13 more
doaj   +1 more source

Phenotypic characteristics of paroxysmal dyskinesia in 25 cats

Journal of Small Animal Practice, EarlyView.
Objectives Paroxysmal dyskinesia has, to date, been reported only systematically in Sphynx cats. This study aims to describe paroxysmal dyskinesia in additional breeds. Materials and Methods The medical records of cats from multiple hospitals presenting with episodes consistent with paroxysmal dyskinesia between 2020 and 2025 were retrospectively ...
T. Liatis, C. Maeso, A. De Stefani, A. Pergande, T. Elvira, A. Suñol   +5 more
wiley   +1 more source

Optimizing Pneumocystis jirovecii Prophylaxis in Immunocompromised Patients: Defining the Clinical Role of Atovaquone

Transplant Infectious Disease, EarlyView.
In a retrospective cohort study of 149 patients receiving atovaquone for PJP prophylaxis, increased usage was related to broader indications, uptake in new patient groups, difficulty tolerating or accessing alternatives, and longer durations used per patient.
To N. Pham, Kelly A. Cairns, Adithi Ramachandra, Susan G. Poole, Carmela E. Corallo, Bradley J. Gardiner   +5 more
wiley   +1 more source

The Plasmodium berghei Ca(2+)/H(+) exchanger, PbCAX, is essential for tolerance to environmental Ca(2+) during sexual development. [PDF]

, 2013
Ca(2+) contributes to a myriad of important cellular processes in all organisms, including the apicomplexans, Plasmodium and Toxoplasma. Due to its varied and essential roles, free Ca(2+) is tightly regulated by complex mechanisms.
Staines, Henry M., David S Guttery, Wheatley Sally P., Guttery, DS, Dominique Soldati-Favre (79026), Leon R. McFarlane (7795319), Sally P. Wheatley (7750238), Soldati-Favre, D, Pittman, Jon K, Tewari Rita, Jon K Pittman, Sally P. Wheatley (384069), Wheatley, Sally P., Frénal, K, Sanjeev Krishna (4917), Leon R McFarlane, Benoit Poulin (134241), Wheatley, SP, Frénal Karine, Dominique Soldati-Favre, Ksenija Slavic (384068), Karine Frénal, Staines, Henry M, Sanjeev Krishna, Guttery, David S, Poulin, Benoit, Frénal, Karine, McFarlane, Leon R, Rita Tewari, Karine Frénal (384066), Ksenija Slavic, Guttery, David S., Tewari, R, Tewari, Rita, Poulin Benoit, Pittman Jon K., Pittman, JK, Poulin, B, Rita Tewari (134257), Henry M Staines, Henry M. Staines (7795322), McFarlane, Leon R., Krishna Sanjeev, Soldati-Favre Dominique, Pittman, Jon K.; id_orcid, Slavic, Ksenija, McFarlane Leon R., Staines Henry M., McFarlane, LR, Jon K. Pittman (127550), Guttery David S., Staines, HM, Krishna, S, Slavic Ksenija, Krishna, Sanjeev, Slavic, K, David S. Guttery (134240), Sally P Wheatley, Leon R. McFarlane (384067), Henry M. Staines (384070), David S. Guttery (7629998), Soldati-Favre, Dominique, Benoit Poulin, Wheatley, Sally P   +63 more
core   +1 more source

Effects of aqueous leaf extracts of Azadirachta indica A. Juss. (neem) and Melia azedarach L. (Santa Barbara or cinnamon) on the intracellular development of Toxoplasma gondii Efeito de extrato aquoso de folhas de Azadirachta indica A. Juss. (nim) e Melia azedarach L. (canela ou Santa Bárbara) sobre o desenvolvimento intracelular de Toxoplasma gondii

Revista Brasileira de Plantas Medicinais, 2011
Melia azedarach (cinnamon) and Azadirachta indica (neem) have a variety of biologically active ingredients against virus, bacteria and protozoan parasites; however, little is known about their action on Toxoplasma gondii intracellular development ...
E.J.T Melo, K.J Vilela, C.S Carvalho
doaj   +1 more source