Results 11 to 20 of about 14,606 (97)

The VEGFR/PDGFR tyrosine kinase inhibitor, ABT-869, blocks necroptosis by targeting RIPK1 kinase

Biochemical Journal, 2023
Necroptosis is a mode of programmed, lytic cell death that is executed by the mixed lineage kinase domain-like (MLKL) pseudokinase following activation by the upstream kinases, receptor-interacting serine/threonine protein kinase (RIPK)-1 and RIPK3 ...
C. Pierotti, Annette V. Jacobsen, Christoph Grohmann, Ruby K. Dempsey, Nima Etemadi, Joanne M. Hildebrand, Cheree Fitzgibbon, Samuel N. Young, K. Davies, Wilhelmus J. A. Kersten, J. Silke, K. Lowes, Hélène Jousset Sabroux, D. Huang, M. V. van Delft, James M. Murphy, G. Lessene   +16 more
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Erratum to “Various Empirical Equations to Unify between the Gravitational Force and the Electromagnetic Force” [Journal of Modern Physics 12 (2021) 859-869]

Journal of Modern Physics, 2021
The original online version of this article (Miyashita, T. (2021) Various Empirical Equations to Unify between the Gravitational Force and the Electromagnetic Force, Journal of Modern Physics, Vol. 12, 859-869.
T. Miyashita
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Machine learning-enabled phenotyping for GWAS and TWAS of WUE traits in 869 field-grown sorghum accessions

bioRxiv, 2020
Sorghum is a model C4 crop made experimentally tractable by extensive genomic and genetic resources. Biomass sorghum is also studied as a feedstock for biofuel and forage.
John N. Ferguson, Samuel B. Fernandes, B. Monier, Nathan D Miller, Dylan Allan, Anna Dmitrieva, Peter Schmuker, R. Lozano, R. Valluru, E. Buckler, M. Gore, P. Brown, E. Spalding, A. Leakey   +13 more
semanticscholar   +1 more source

Nucleophosmin mutations confer an independent favorable prognostic impact in 869 pediatric patients with acute myeloid leukemia

Blood Cancer Journal, 2020
Studies on the clinical significance of Nucleophosmin (NPM1) mutations in pediatric AML in a large cohort are lacking. Moreover, the prognosis of patients with co-occurring NPM1 and FLT3/ITD mutations is controversial.
Lu-Hong Xu, Jianpei Fang, Yao-Chung Liu, Adrianna I Jones, L. Chai   +4 more
semanticscholar   +1 more source

Determinants of the decline in mortality from acute stroke in England: linked national database study of 795 869 adults

British medical journal, 2019
Objectives To study trends in stroke mortality rates, event rates, and case fatality, and to explain the extent to which the reduction in stroke mortality rates was influenced by changes in stroke event rates or case fatality.
O. Seminog, P. Scarborough, F. L. Wright, M. Rayner, Michael J Goldacre   +4 more
semanticscholar   +1 more source

Cell stiffness under small and large deformations measured by optical tweezers and atomic force microscopy: effects of actin disruptors CK-869 and jasplakinolide

, 2020
Cytoskeleton-disrupting drugs can have different effects on cell mechanics at different deformation scales. We therefore applied two complementary indentation techniques to study the effects of two actin-disrupting drugs on cellular stiffness of human ...
Š. Z. Jokhadar, J. Iturri, J. Toca-Herrera, J. Derganc   +3 more
semanticscholar   +1 more source

Relationship between TGF-β1 + 869 T/C and + 915 G/C gene polymorphism and risk of acute rejection in renal transplantation recipients

BMC Medical Genetics, 2019
BackgroundThis meta-analysis was conducted to assess the relationship between the transforming growth factor-beta 1 (TGF-β1) + 869 T/C gene polymorphism, + 915 G/C gene polymorphism, and the susceptibility of acute rejection in the recipients with renal ...
Hong-Yan Li, Tianbiao Zhou, Shujun Lin, Wenshan Lin   +3 more
semanticscholar   +1 more source

Linifanib (ABT-869) Potentiates the Efficacy of Chemotherapeutic Agents through the Suppression of Receptor Tyrosine Kinase-Mediated AKT/mTOR Signaling Pathways in Gastric Cancer

Scientific Reports, 2016
Gastric cancer, highly dependent on tumor angiogenesis, causes uncontrolled lethality, in part due to chemoresistance. Here, we demonstrate that linifanib (ABT-869), a novel multi-targeted receptor tyrosine kinase inhibitor, markedly augments ...
Jing Chen, Jiawei Guo, Zhi Chen, Jieqiong Wang, Mingyao Liu, Xiufeng Pang   +5 more
semanticscholar   +1 more source

CK-666 and CK-869 differentially inhibit Arp2/3 iso-complexes

bioRxiv
The inhibitors, CK-666 and CK-869, are widely used to probe the function of actin nucleation by the Arp2/3 complex in vitro and in cells. However, in mammals, the Arp2/3 complex consists of 8 iso-complexes, as three of its subunits (Arp3, ArpC1, ArpC5 ...
LuYan Cao, S. Huang, Angika Basant, M. Mladenov, Michael Way   +4 more
semanticscholar   +1 more source

The role of TGF-β1 869 T > C and PPAR γ2 34 C > G polymorphisms, fat mass, and anthropometric characteristics in predicting childhood obesity at birth

Medicine, 2016
This study proposed to establish a correlation between the risk score for child obesity and anthropometric, genetic, and bioimpedance characteristics in mothers and newborns, and to assess the discriminant ability for anthropometric parameters to ...
C. Mǎrginean, C. O. Mǎrginean, M. Iancu, B. Szabó, Manuela Cucerea, L. Meliț, A. Crauciuc, C. Bănescu   +7 more
semanticscholar   +1 more source