Results 21 to 30 of about 1,335 (104)
Clinical and Translational Discovery, Volume 3, Issue 5, October 2023., 2023 In this study, we pool publicly available gene expression data from clinical samples (tissue biopsies and blood samples) and derive and validate a signature of consistently deregulated genes across pancreatic ductal adenocarcinoma (PDAC) samples.
Aristeidis Sionakidis +3 more
wiley +1 more source
Human amygdala involvement in Alzheimer's disease revealed by stereological and dia‐PASEF analysis
Brain Pathology, Volume 33, Issue 5, September 2023., 2023 A combined stereological and proteomic analysis revealed amygdala volume reduction linked to synaptic dysfunction in Alzheimer''s disease samples. The pathological markers gradient suggested the relevance of connections in the distribution of the pathology among different brain regions.
Melania Gonzalez‐Rodriguez +7 more
wiley +1 more source
Journal of Extracellular Vesicles, Volume 12, Issue 8, August 2023., 2023 Abstract Small extracellular vesicles (sEVs) play a key role in exchanging cargoes between cells in tumour microenvironment. This study aimed to elucidate the functions and mechanisms of hepatocellular carcinoma (HCC) derived sEV‐clathrin light chain A (CLTA) in remodelling microvascular niche.
Yi Xu +14 more
wiley +1 more source
Tumor protein D52 (TPD52) affects cancer cell metabolism by negatively regulating AMPK
Cancer Medicine, Volume 12, Issue 1, Page 488-499, January 2023., 2023 TPD52 forms a stable complex with AMPKα and negatively regulates AMPKα kinase activity. TPD52 modulates cell metabolism through regulating AMPK. Abstract Background The AMP‐activated protein kinase (AMPK) is a central regulator of energy homeostasis, with deregulation leading to cancer and other diseases.
Yali Chen +8 more
wiley +1 more source
, 2023 BackgroundTumor Protein D52-Like 2 (TPD52L2) is a tumor-associated protein that participates in B-cell differentiation. However, the role of TPD52L2 in the pathological process of clear cell renal cell carcinoma (ccRCC) is unclear.MethodsMultiple omics ...
Panfeng Shang (8376273) +6 more
core +1 more source
Intracellular nanovesicles mediate α5β1 integrin trafficking during cell migration [PDF]
, 2021 Membrane traffic is an important regulator of cell migration through the endocytosis and recycling of cell surface receptors such as integrin heterodimers.
Stephen J. Royle +31 more
core +1 more source
, 2021 Tumor protein D52-like 2 (TPD52L2) belongs to the members of the TPD52 family. TPD52L2 was reported to regulate proliferation and apoptosis in cancer cells. However, its role in lung adenocarcinoma (LUAD) was uncertain.
Anyuan Zhong (629889) +4 more
core +1 more source
FEBS Letters, Volume 596, Issue 18, Page 2382-2399, September 2022., 2022 Identifying interactomes of membrane‐associated small G proteins is challenging. Here, we applied three proteomic approaches to identify the interactive neighbourhood of constitutively active Arl5b, a small G protein of the trans‐Golgi network (TGN). 50% of the hits were TGN/Golgi‐localised small G proteins, indicating an organised complex of small G ...
Fiona J. Houghton +4 more
wiley +1 more source
, 2021 Tumor protein D52-like 2 (TPD52L2) belongs to the members of the TPD52 family. TPD52L2 was reported to regulate proliferation and apoptosis in cancer cells. However, its role in lung adenocarcinoma (LUAD) was uncertain.
Anyuan Zhong (629889) +4 more
core +1 more source
Journal of Comparative Neurology, Volume 530, Issue 11, Page 1773-1949, August 2022., 2022 By using a genetically modified mouse model and viral tracing approaches, we mapped both the anterograde and the retrograde projections of a subpopulation of neurons in the anterior paraventricular thalamic nucleus, molecularly defined by the expression of glucokinase (GckaPVT).
Sevasti Gaspari +4 more
wiley +1 more source