Results 41 to 50 of about 8,384 (285)

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

IoT-TPMS

International journal of health sciences, 2022
In general, the number of diseases is increasing in the current era. There is also a growing fear among the patients about the nature of the growing number of new diseases and their consequences. Thus the patients are interested in getting treatment from healthcares for minor physical problems.
J Logeshwaran, Javid Ahmad Malik, Nirmal Adhikari, Sidharth Srikant Joshi, Pooja Bishnoi   +4 more
openaire   +1 more source

Using cell‐free RNA to identify B‐ and T‐cell clonality for diagnosis and monitoring of B‐ and T‐cell neoplasms

FEBS Open Bio, EarlyView.
Using peripheral blood for determining B‐cell or T‐cell clonality is more reliable when we use cell‐free RNA (cfRNA) because cells release blood significantly more RNA than DNA. Next‐generation sequencing (NGS) of cfRNA allows us to evaluate fragment cfRNA and evaluate clonality reliably without the need for prior determination of the specific dominant
Adam Albitar, Sally Agersborg, Ahmed Charifa, Pooja Phull, Noa Biran, David Vesole, Harsh Parmar, Andrew Pecora, Andrew Ip, Andre Goy, David Siegel, Maher Albitar   +11 more
wiley   +1 more source

Energy absorption of gradient triply periodic minimal surface structure manufactured by stereolithography

Reviews on Advanced Materials Science
Triply periodic minimal surface (TPMS) metamaterials possess exceptional properties not commonly found in natural materials. TPMS metamaterials are used in lightweight structures and impact energy absorption structures due to their surface geometry and ...
Liang Yingjing, He Huiyi, Yin Jun, Liu Yijie, Huang Jianzhang, Wu Zhigang, Zhai Yun, Hui David, Yan Lewei   +8 more
doaj   +1 more source

Standard transition probability matrix sets (TPMS) and the datasets used to develop TPMS.

, 2016
Standard transition probability matrix sets (TPMS) and the datasets used to develop TPMS.
Natacha à Porta (2585776), Dina Jankovic (2585770), Arminder Deol (2585779), Antonio Montresor (217485), Nam Lethanh (2585773)   +4 more
core   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

FEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Integrated PANoptosis Profiling Identifies Immunosuppressive Subtypes and a Prognostic Signature With Functional Validation of MLKL in Glioblastoma

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The prognosis of glioblastoma (GBM) remains highly unfavorable, largely due to high tumor heterogeneity and an immunosuppressive microenvironment. However, the functional role of PANoptosis in this context is poorly understood. Methods Patients were stratified via K‐means clustering. A risk score model was constructed using prognosis‐
Langfei Tian, Minghui Zhao, Yuanbo Hu, Kaiyue Wang, Haiguang Liu, Zetong Bai, Kebin Zheng   +6 more
wiley   +1 more source

Bending behavior of additively manufactured short fiber reinforced composite sandwich structures based on triply periodic minimal surface

Polymer Testing
Triply periodic minimal surfaces (TPMSs) have gained increasing attention because of their excellent mechanical properties and scalability. The Gyroid TPMS core sandwich (G-TPMS sandwich) structure was designed, and its bending performance and failure ...
Yaozhong Wu, Xuepeng Li, Shaoan Li, HuaWei Wang, Peng Wang, Weijia Li   +5 more
doaj   +1 more source

Flexural Behavior of 3D‐Printed Porous Bouligand‐Structured Polymers: Influence of Pitch Angle and Porosity

Advanced Engineering Materials, EarlyView.
This study examines how helicoidal architectures with different porosities respond to bending. Adjusting layer angle and spacing in 3D‐printed polymers reveals clear tradeoffs between stiffness, strength, and energy absorption. Experiments and simulations highlight designs that distribute stress effectively, offering pathways for optimizing lightweight
Praveenkumar Subhash Patil, Edward D. McCarthy, Parvez Alam   +2 more
wiley   +1 more source