Results 131 to 140 of about 120,185 (299)

Phenotypic Subtypes of Obstructive Eustachian Tube Dysfunction as Defined by Cluster Analysis

The Laryngoscope, EarlyView.
Obstructive ETD encompasses five clinically distinct phenotypes, ranging from mild, post‐upper respiratory infection presentations to chronic, bilateral disease driven by sinusitis and reflux. These were identified through hierarchical cluster analysis of 490 patients using seven key clinical variables.
Jenilkumar H. Patel, Duncan G. J. Green, Manal S. Malik, Steven X. Wang, Edward D. McCoul   +4 more
wiley   +1 more source

Polymerized Pro‐Estrogen Microneedles via Two Photon Polymerization

Macromolecular Rapid Communications, EarlyView.
Acrylic pro‐drugs of 17β‐estradiol were subjected to spatially controlled two‐photon polymerization to create bespoke microneedle geometries with potential biomedical applications for long‐term transdermal hormone delivery. ABSTRACT Two‐photon polymerization (TPP) is a powerful technique to create microscale structures with high precision, offering ...
Yang Lou, John T. Leman, Harper Serringer, Ke Xia, Christopher N. LaFratta, Chaitanya Ullal, Edmund F. Palermo   +6 more
wiley   +1 more source

Mass Spectrometry Structural Proteomics Enabled by Limited Proteolysis and Cross‐Linking

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The exploration of protein structure and function stands at the forefront of life science and represents an ever‐expanding focus in the development of proteomics. As mass spectrometry (MS) offers readout of protein conformational changes at both the protein and peptide levels, MS‐based structural proteomics is making significant strides in the
Haiyan Lu, Zexin Zhu, Lauren Fields, Hua Zhang, Lingjun Li   +4 more
wiley   +1 more source

Benthic megafauna and the functioning of macroalgal forests and urchin barrens

Oikos, EarlyView.
Two temperate rocky reef food‐web models, representing the trophic diversity of the Mediterranean rocky reef communities, were built for the two stable states: macroalgal forests and barren grounds, which are characterized by opposite amounts of erect macroalgal biomass.
Chiara Bonaviri, Davide Agnetta, Stefania Pinna, Luigi Piazzi, Fabio Badalamenti, Giulia Ceccherelli, Davide Iaciofano, Manfredi Di Lorenzo, Francesco Di Trapani, Sabrina Lo Brutto, Vesna Mačić, Anna Maria Mannino, Francesco Mura, Luigi Musco, Laura Tamburello, Tomás Vega Fernández, Salvatrice Vizzini, Trevor Willis, Paola Gianguzza   +18 more
wiley   +1 more source

Harnessing Phytochemicals for Brain Cancer Therapy: Insights Into Medulloblastoma and Glioblastoma Treatment

Phytochemical Analysis, EarlyView.
ABSTRACT Primary brain tumors are life‐threatening diseases. Glioblastoma is the most aggressive type with a poor prognosis. Medulloblastoma is the most common pediatric brain tumor. While surgical treatments often result in recurrences owing to the complex nature of the tumor microenvironment, conventional treatments lower the quality of life of ...
Ilkay Irem Ozbek, Mesra Aktas, Hale Saybasili, Kutlu O. Ulgen   +3 more
wiley   +1 more source

Third-party punishment-like behavior in a rat model

Scientific Reports
Third-party punishment (TPP) is an altruistic behavior or sense willing to punish transgressors as a third party not directly involved in the transgression.
Kanta Mikami, Yuka Kigami, Tomomi Doi, Mohammed E. Choudhury, Yuki Nishikawa, Rio Takahashi, Yasuyo Wada, Honoka Kakine, Mayuu Kawase, Nanae Hiyama, Hajime Yano, Naoki Abe, Tasuku Nishihara, Junya Tanaka   +13 more
doaj   +1 more source

Cationic‐Hydrophilic Di‐Block Copolymers: Surface‐Shielded Vectors for Gene Delivery

Journal of Polymer Science, Volume 63, Issue 6, Page 1419-1432, 15 March 2025.
This study develops synthetic polycationic di‐block carriers for nucleic acid (NA) delivery in gene therapy. Consisting of a cationic block and a hydrophilic block, these carriers efficiently form complexes with NAs and shield them with a protective bioinert layer, enhancing stability during circulation in the bloodstream while reducing undesirable ...
Eliška Hrdá, Ladislav Androvič, Marcela Filipová, Michal Pechar, Richard Laga   +4 more
wiley   +1 more source

Chitosan‐protected dsRNA increases efficacy against Helicoverpa armigera without compromising biosafety for pollinators

Pest Management Science, EarlyView.
Chitosan/tripolyphosphate/double‐stranded RNA (dsRNA) nanoparticles enhance RNA interference efficacy of orally delivered dsRNA against Helicoverpa armigera. Nanoparticles reduce the LC50 and do not cause deleterious effects or toxicity on beneficial insects.
Daniel DN Vasquez, Lays A Teixeira, Rangel F Alves, Raire Cavalcante, Leonardo LP Macedo, Carmen SS Pires, Luciano P Silva, Maria CM Silva, Feras M Afifi, Carolina V Morgante, Martin G Edwards, Angharad MR Gatehouse, Maria F Grossi‐de‐Sa   +12 more
wiley   +1 more source

From 0D to 3D liquid crystal elastomers architectures: Fabrications and applications

Responsive Materials, EarlyView.
This review presents a dimension‐oriented overview of liquid crystal elastomers (LCEs), highlighting their molecular alignment, fabrication strategies, and programmable deformations from 0D particles to 3D architectures. Emphasis is placed on how dimensionality guides design principles, enables diverse actuation modes, and bridges fundamental ...
Mingxuan Liu, Zongxuan Wu, Jinquan Zheng, Yidan Zhu, Yanjun Liu, Lingling Ma, Wei Hu, Yan‐Qing Lu, Dan Luo   +8 more
wiley   +1 more source

The scale matters: A review on stimuli‐responsive microrobots categorized by scale for biomedical applications

Responsive Materials, EarlyView.
We systematically summarize how each scale dictates fundamental choices in design feature, manufacturing technology, driving mechanism, and control strategy, which are inherently governed by scale‐dominated physical principles. Furthermore, the application of scale‐determined operation modes of microrobots across different stages of medical ...
Hang Yin, Yujing Li, Guanghao Wu, Yubing Guo   +3 more
wiley   +1 more source