Results 71 to 80 of about 127,031 (300)

Sexually dimorphic tibia shape is linked to natural osteoarthritis in STR/Ort mice [PDF]

, 2018
Human osteoarthritis (OA) is detected only at late stages. Male STR/Ort mice develop knee OA spontaneously with known longitudinal trajectory, offering scope to identify OA predisposing factors.
A.A. Pitsillides, Altman, Arden, B. Javaheri, Bailey, Baliunas, Burger, Callewaert, Chambers, Chambers, Comhaire, Cooper, Das-Gupta, De Souza, Doube, Felson, Felson, Glasson, Goldring, Gregson, Guettler, H. Razi, Hardcastle, Hardcastle, Hardcastle, I. Maric-Mur, Javaheri, Javaheri, Javaheri, Kilkenny, Kyostio-Moore, Lajeunesse, Longo, M. Hopkinson, M. Piles, Mason, Naruse, Nevitt, P.D. Lee, Pasold, Poulet, Poulet, R. de Souza, Razi, Schneider, Sharma, Silverstein, Sowers, Spector, Stok, Strong, Tetsworth, Uchida, Vincelette, Walton, Walton, Y.-M. Chang, Zhang   +57 more
core   +4 more sources

Laser‐Assisted Processing and Modification of Bioactive Glasses: A Review

Advanced Healthcare Materials, EarlyView.
Laser technologies provide powerful tools to process and transform bioactive glasses for advanced biomedical applications. This review discusses laser‐matter interaction mechanisms, laser surface engineering, and laser‐assisted fabrication of scaffolds and nanofibers.
Antonio Riveiro, Mario González‐Quintas, Mónica Fernández‐Arias, Jesús del Val, Félix Quintero, Rafael Comesaña, Fernando Lusquiños, Julian R. Jones, Juan Pou   +8 more
wiley   +1 more source

Incorporating tissue anisotropy and heterogeneity in finite element models of trabecular bone altered predicted local stress distributions [PDF]

, 2017
Trabecular bone is composed of organized mineralized collagen fibrils, which results in heterogeneous and anisotropic mechanical properties at the tissue level.
Allen, Matthew R., Hammond, Max A., Siegmund, Thomas, Wallace, Joseph M.   +3 more
core   +1 more source

SiO2‐CaOCME/Poly(Tetrahydrofuran)/Poly(Caprolactone) 3D‐Printed Scaffolds Drive Human‐Bone Marrow Stromal Cell Osteogenic Differentiation

Advanced Healthcare Materials, EarlyView.
3D printed hybrid scaffolds combining bioactive silica–calcium chemistry with elastic polymers guide human bone stem cells to form bone. The scaffolds support cell survival, organization, and invasion while releasing osteogenic ions. Together, architecture and composition drive bone‐specific gene expression, extracellular matrix organization, and ...
David R. Sory, Agathe C.M. Heyraud, Julian R. Jones, Sara M. Rankin   +3 more
wiley   +1 more source

Characterization of an Injectable Poly(vinyl alcohol)‐gelatin Hydrogel for Growth Factor Delivery in an Orthopedic Application

Advanced Healthcare Materials, EarlyView.
This work introduces photo‐crosslinkable tyraminated poly(vinyl alcohol)‐gelatin (PVA‐GT) hydrogels as tunable injectable platforms for tissue engineering and growth factor delivery applications. This schematic illustrates the two developed hydrogel formulations and the experimental workflow used to evaluate their physico‐chemical properties in vitro ...
Alessia Longoni, Gretel S. Major, Sam Arnold, Samuel Tomkins, Eugenia Spessot, Scott Loeffler, Kieran Lau, Richard Tan, Jessica Harte, Roslyn Kemp, Tess Reynolds, Jelena Rnjak‐Kovacina, Gary J. Hooper, Tim B. F. Woodfield, David C. Kieser, Khoon S. Lim   +15 more
wiley   +1 more source

Phospho1 deficiency transiently modifies bone architecture yet produces consistent modification in osteocyte differentiation and vascular porosity with ageing [PDF]

, 2015
PHOSPHO1 is one of principal proteins involved in initiating bone matrix mineralisation. Recent studies have found that Phospho1 KO mice (Phospho1-R74X) display multiple skeletal abnormalities with spontaneous fractures, bowed long bones, osteomalacia ...
Carriero, A, Chang, Y M, Farquharson, C, Houston, D A, Javaheri, B, Kazeruni, B N, Millan, J L, Oldknow, K J, Pitsillides, A A, Salmon, P, Shefelbine, S, Staines, K A   +11 more
core   +4 more sources

A digital model of trabecular bone

Journal of Bone and Mineral Research, 1996
Abstract A 3D μCT dataset of bovine bone was used to create a digital 3D model simulating trabecular bone. The model serves a dual purpose: It allows for standard quantitative histomorphometric analysis and it approximates the reality e.g. of high resolution CT in vivo datasets of trabecular bone.
K, Engelke, S M, Song, C C, Glüer, H K, Genant   +3 more
openaire   +2 more sources

Heme compounds in dinosaur trabecular bone [PDF]

Proceedings of the National Academy of Sciences, 1997
Six independent lines of evidence point to the existence of heme-containing compounds and/or hemoglobin breakdown products in extracts of trabecular tissues of the large theropod dinosaur Tyrannosaurus rex . These include signatures from nuclear magnetic resonance and electron spin resonance that indicate the ...
M H, Schweitzer, M, Marshall, K, Carron, D S, Bohle, S C, Busse, E V, Arnold, D, Barnard, J R, Horner, J R, Starkey   +8 more
openaire   +2 more sources

A Modular Bioinstructive Platform Reveals Mechanistic Insights into Additive‐Free, Topography‐Driven Osteogenesis

Advanced Healthcare Materials, EarlyView.
Engineered microparticle topographies direct human mesenchymal stem cell osteogenesis without biochemical additives. This osteogenic commitment is driven by canonical Hedgehog signaling and followed by temporal IGF‐II engagement. Two‐photon polymerization demonstrates spatial control, enabling the engineering of topographical gradients that pattern ...
Fatmah I. Ghuloum, Leo A. H. Zeef, Lee A. Stevens, Marco A. N. Domingos, Susan J. Kimber, Mahetab H. Amer   +5 more
wiley   +1 more source

Multiscale experimental study on the effects of different weight-bearing levels during moderate treadmill exercise on bone quality in growing female rats

BioMedical Engineering OnLine, 2019
Background Bone tissue displays a hierarchical organization. Mechanical environments influence bone mass and structure. This study aimed to explore the effects of different mechanical stimuli on growing bone properties at macro–micro–nano scales. Methods
Juan Fang, Jiazi Gao, He Gong, Tianlong Zhang, Rui Zhang, Bangchao Zhan   +5 more
doaj   +1 more source