Results 151 to 160 of about 16,541 (253)

Sustained Hypoxia‐Inducible Factor 1‐Alpha Accumulation Disrupts the Articular Niche to Promote Osteoarthritis Pathogenesis

Aging Cell, Volume 25, Issue 7, July 2026.
Sustained HIF‐1α accumulation is not a compensatory shield, but a potent pathogenic driver of osteoarthritis. Continuous HIF‐1α signaling physically eradicates the avascular cartilage niche and primes the synovium for inflammation, establishing HIF‐1α as a critical target for disease‐modifying therapies.
Weiyuan Gong, Chu Tao, Xingyun Wang, Rongdong Liao, Jianglong Li, Xiongtian Guo, Minghao Qu, Jianmei Huang, Mingjue Chen, Fuxin Wei, Peng Wang, Lijun Lin, Di Chen, Qing Yao, Chunyi Wen, Guozhi Xiao   +15 more
wiley   +1 more source

Variable electrophysiology before and after block of the two delayed rectifier potassium channels in groups of isolated rabbit ventricular cells

British Journal of Pharmacology, Volume 183, Issue 13, Page 3685-3705, July 2026.
Abstract Background and Purpose Between‐cell differences in ventricular cardiomyocyte action potential duration (APD) and responses to ion channel block may contribute to pro‐arrhythmic dispersion of myocardial repolarisation. This study quantifies between‐cell physiological and pharmacological variability in the rabbit left ventricle (LV) and uses ...
Rebecca J. Gilchrist, Muhamad Hifzhudin Noor Aziz, Francis L. Burton, Radostin D. Simitev, Rachel C. Myles, Godfrey L. Smith   +5 more
wiley   +1 more source

Proteolysis at the extracellular matrix interface: Molecular architects and regulators in health and disease

The FEBS Journal, Volume 293, Issue 13, Page 3758-3787, July 2026.
The extracellular matrix (ECM) is a dynamic scaffold that orchestrates tissue architecture and cellular communication. A critical but underexplored interplay between proteases and cluster of differentiation molecules (CD) governs ECM turnover and directs cell fate.
David Jurnečka, Matija Hrovatin, Bor Bokalj, Boris Turk   +3 more
wiley   +1 more source

Oxypaeoniflorin Ameliorates Titanium Particle‐Stimulated Osteolysis by Targeting Nrf2 to Reprogram Mitochondrial Homeostasis in Osteoclasts

Journal of Cellular and Molecular Medicine, Volume 30, Issue 13, July 2026.
ABSTRACT Wear debris surrounding implants plays a crucial role in the development of periprosthetic osteolysis (PPO) by inducing the aggregation of osteoclasts around the prosthesis. Oxypaeoniflorin (OPF), a derivative of Paeoniflorin, is primarily sourced from the root of the traditional Chinese medicine peony and possesses anti‐inflammatory and ...
Feng Zhu, Zebin Wu, Jinxuan Hei, Huaqiang Tao, Wenming Li, Kai Chen, Qihan Wang, Dechun Geng, Zhidong Wang, Yaozeng Xu, Shujun Lv   +10 more
wiley   +1 more source

Variation in trabecular bone microarchitecture across rhesus macaque (Macaca mulatta) load‐bearing joints

Journal of Anatomy, Volume 249, Issue 1, Page 97-113, July 2026.
Aging of bone density (BV/TV) is regional: Forelimb [left] elements gain bone sporadically (orange) but hind limb elements [right] lose bone globally (blue). Abstract Globally, human population structure is quickly trending older, increasing the prevalence and systemic burden of age‐related skeletal disorders such as osteoporosis.
Cassandra M. Turcotte, Aditi Raghunath, Timothy M. Ryan, Lily J. D. DeMars, Erin Siracusa, Sam K. Patterson, Cayo Biobank Research Unit, Michael L. Platt, Lauren J. N. Brent, Noah Snyder‐Mackler, Samuel E. Bauman, Michael J. Montague, Melween I. Martinez, Scott A. Williams, Susan C. Antón, James P. Higham, Sharon Kuo   +16 more
wiley   +1 more source

Hepatocyte Growth Factor Confers Trabecular Meshwork Stem Cell Resilience and Paracrine Protection of Trabecular Meshwork Cells in Glaucoma. [PDF]

Invest Ophthalmol Vis Sci
Du R, Yang E, Ayyala R, Du Y.
europepmc   +1 more source

Short‐Term Daily Oral Administration of Cannabidiol Does Not Impact Rebound Tonometry Intraocular Pressure or Schirmer Tear Test Values in Healthy Adult Horses

Veterinary Ophthalmology, Volume 29, Issue 4, July 2026.
ABSTRACT Objective To assess the effect of orally administered cannabidiol (CBD) on TonoVet measured intraocular pressure (IOP) and Schirmer tear test I (STT) in horses. Animal Studied Horse. Procedure This was a masked, randomized, balanced cross‐over study of six healthy adult horses.
Kathryn Diehl, Colleen Sheridan, Rachel Reed   +2 more
wiley   +1 more source

Cross-linked actin networks (CLANs) and their role in the trabecular meshwork. [PDF]

Exp Eye Res
Huang A, Dalloul JM, Sugali CK, Dhamodaran K, Dai J, Rai A, McLellan GJ, Mao W.   +7 more
europepmc   +1 more source

Prospective in silico trials identify combined SK and K2P channel block as an effective strategy for atrial fibrillation cardioversion

The Journal of Physiology, Volume 604, Issue 13, Page 5221-5235, 1 July 2026.
Abstract figure legend In silico trials were conducted in 654 virtual patients with atrial fibrillation (AF) to assess the cardioversion efficacy of three pharmacological treatments: single SK and K2P channel block and combined SK+K2P channel inhibition. Left: representative virtual AF patient with the atria inside the torso.
Albert Dasí, Lucas Arantes Berg, Hector Martinez‐Navarro, Alfonso Bueno‐Orovio, Blanca Rodriguez   +4 more
wiley   +1 more source

Region-Specific Alterations in the Trabecular Meshwork in High- and Low-Tension Glaucoma. [PDF]

Cureus
Rao A, Muduli KC, Sucharita S.
europepmc   +1 more source