Preventing secondary primary malignancies (SPMs) in CAR-T cell therapy through site-specific transgene integration into genomic safe harbors (GSHs). [PDF]
Safarzadeh Kozani P +1 more
europepmc +1 more source
High-efficiency homology-directed insertion into the genome using the engineered homing endonuclease ARCUS. [PDF]
Resly LC +13 more
europepmc +1 more source
c-JUN enhances CRISPR knockin anti-B7-H3 CAR T cell function in small cell lung cancer and thoracic SMARCA4-deficient undifferentiated tumors. [PDF]
Balke-Want H +25 more
europepmc +1 more source
Orthogonal CRISPR systems for targeted integration and multiplex base editing enable nonviral engineering of allogeneic CAR-T cells. [PDF]
Mikkelsen NS +8 more
europepmc +1 more source
The assembly of a hybrid type IV secretion system by a Crohn's disease-associated Escherichia coli strain. [PDF]
Wong J +15 more
europepmc +1 more source
Multiplex engineering and multifunction T cells for precise and effective immunotherapies. [PDF]
Jafarzadeh L, Smaani A, Delisle JS.
europepmc +1 more source
CRISPR tools for T cells: targeting the genome, epigenome, and transcriptome. [PDF]
Wachsmann TLA, Qi LS.
europepmc +1 more source
Harnessing the potential of gene editing technology for CAR-T cell therapy of solid tumors. [PDF]
Khodabandehloo E +5 more
europepmc +1 more source

