Results 31 to 40 of about 15,334 (193)

Generation of CCR4/CD7 Bispecific CAR‐T Cells Resistant to Fratricide and Exhaustion

Advanced Science, EarlyView.
The applications of CAR T‐cell therapy in T‐cell malignancies face limitations such as fratricide, effector‐cell exhaustion, and antigen‐escape. Herein, we developed fratricide‐ and exhaustion‐resistant CAR‐T cells that targeted CCR4 and CD7 simultaneously, with optional EGFRt safety switch. Additionally, scRNA‐seq unveiled new molecular targets, which
Sile Li, Yuanxin Li, Asif Rashid, Hong Kee Tan, Shing Chan, Man Yan Hui, Wilson Yau Ki Chan, Kee See Lam, Yinping Liu, Wenwei Tu, Wing Leung   +10 more
wiley   +1 more source

Bona Fide Intersegmental Plane Hepatectomy Along the Glissonean Branches (BIPHG)

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT This review traces the author's personal journey over three decades in the evolution of liver resection techniques, culminating in the proposal of the Bona Fide Intersegmental Plane Hepatectomy Along Glissonean Branches (BIPHG). Beginning with pioneering experiences in laparoscopic and robotic liver surgeries, the author highlights key ...
Go Wakabayashi, Taiga Wakabayashi
wiley   +1 more source

Graman Revisited Once Again: A Reanalysis of the Late Holocene Legacy Faunal Assemblage From GB4 Rockshelter, New South Wales

Archaeology in Oceania, EarlyView.
ABSTRACT The archaeological site Graman B4 provided one of the first records of substantial dietary change in ancient Australian Aboriginal society. Initial examination of the faunal remains from this site suggested that Late Holocene hunters reduced their focus on high‐ranked kangaroos to increasingly rely on arboreal possums; and that these ...
Loukas George Koungoulos, Jane Balme, Sue O'Connor   +2 more
wiley   +1 more source

The Role of Courts in International Arbitration: A Critical Assessment on the Arbitration Draft Bill in Iran from the Perspective of Modern Arbitration Rules [PDF]

Faṣlnāmah-i Pizhūhish-i Huqūq-i Khuṣūṣī, 2018
The role of courts in international arbitration can scarcely be denied. Courts play a crucial role in different stages in international arbitration. Having said that, the extent of courts' intervention in international arbitration has been subject to ...
Ali Moghaddam Abrishami, Masoud Mahboub
doaj   +1 more source

Flow cytometry‐based monitoring of chimeric antigen receptor (CAR) T cells: Reagent selection, assay design, and clinical utility

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Accurate quantification of chimeric antigen receptor (CAR) T cells is essential for monitoring post‐infusion CART expansion and persistence and for real‐time clinical decision‐making. Multiparameter flow cytometry (MFC) enables rapid, live‐cell detection with absolute quantification and concurrent immunophenotypic characterization. This review
Jianhua Ling, Wei Wang, Sa A. Wang
wiley   +1 more source

Metabolic priming of GD2 TRAC-CAR T cells during manufacturing promotes memory phenotypes while enhancing persistence

Molecular Therapy: Methods & Clinical Development
Manufacturing chimeric antigen receptor (CAR) T cell therapies is complex, with limited understanding of how medium composition impacts T cell phenotypes.
Dan Cappabianca, Dan Pham, Matthew H. Forsberg, Madison Bugel, Anna Tommasi, Anthony Lauer, Jolanta Vidugiriene, Brookelyn Hrdlicka, Alexandria McHale, Quaovi H. Sodji, Melissa C. Skala, Christian M. Capitini, Krishanu Saha   +12 more
doaj   +1 more source

Assessment of Maladaptive Exercise History Among Individuals With Eating Disorders: Validation of a Brief, Self‐Report Measure

European Eating Disorders Review, EarlyView.
ABSTRACT Objective Maladaptive exercise is a common symptom of eating disorders (EDs). While several measures exist to assess current maladaptive exercise, there are no validated self‐report tools to assess maladaptive exercise history—an important symptom domain among individuals with lifetime EDs.
Katherine Schaumberg, Hunna J. Watson, Laura M. Thornton, Hannah L. Kennedy, Shu H. Ong, Preston Roche, Kayla Costello, Wesley R. Barnhart, Sian B. Pauley‐Gadd, Rachael E. Flatt, Andreas Birgegård, Lisa Dinkler, Afrouz Abbaspour, Emma Forsén Mantilla, Elin Monell, Emma M. Frans, Sarah Barakat, Michaela A. Pettie, Richard Parker, Sarah Maguire, Jennifer Jordan, Martin A. Kennedy, Nailah Adams Morancie, Cynthia M. Bulik   +23 more
wiley   +1 more source

Intrapartum oral azithromycin for maternal infection prophylaxis and the risk of postpartum hemorrhage: A secondary analysis of the A‐PLUS trial

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Objective A single oral dose of azithromycin (AZM) given during labor to women planning a vaginal delivery reduced maternal infections including sepsis, with a stronger effect in sub‐Saharan Africa than South Asia. Since maternal infection contributes to labor dysfunction and postpartum hemorrhage (PPH), we evaluated the effect of AZM on the ...
Larissa Sidze, Janet L. Moore, Waldemar A. Carlo, Musaku Mwenechanya, Elwyn Chomba, Jennifer J. Hemingway‐Foday, Avinash Kavi, Mrityunjay C. Metgud, Shivaprasad S. Goudar, Richard Derman, Adrien L. Lokangaka, Antoinette K. Tshefu, Melissa S. Bauserman, Carl L. Bose, Poonam Shivkumar, Manjushri Waikar, Archana B. Patel, Patricia L. Hibberd, Paul Nyongesa, Fabian Esamai, Osayame A. Ekhaguere, Sherri L. Bucher, Saleem Jessani, Shiyam Sunder Tikmani, Sarah Saleem, Robert L. Goldenberg, Sk Masum Billah, Ruth Lennox, Rashidul Haque, William A. Petri, Lester Figueroa, Manolo Mazariegos, Nancy F. Krebs, Tracy L. Nolen, Marion Koso‐Thomas, Elizabeth M. McClure, Alan T. N. Tita, for the A‐PLUS Trial Group   +37 more
wiley   +1 more source

Indirubin and Retinoic Acid Show Binding Affinity to Monocyte Biomarker CSF3R in Parkinson's Disease

Journal of Clinical Laboratory Analysis, EarlyView.
Through single‐cell RNA‐sequencing and high‐dimensional weighted gene co‐expression network analysis, two monocyte‐related biomarkers (CSF3R, IFITM3) were identified in the peripheral blood of Parkinson's disease. Molecular docking revealed two targeted drugs (Indirubin and Retinoic acid).
Zhiwei Bao, Shao Zhi, Mao Jie
wiley   +1 more source

Divergent Evolution of TRC Genes in Mammalian Niche Adaptation

Frontiers in Immunology, 2019
Mammals inhabit a wide variety of ecological niches, which in turn can be affected by various ecological factors, especially in relation to immunity. The canonical TRC repertoire (TRAC, TRBC, TRGC, and TRDC) codes C regions of T cell receptor chains that
Zepeng Zhang, Yuan Mu, Lei Shan, Di Sun, Weijian Guo, Zhenpeng Yu, Ran Tian, Shixia Xu, Guang Yang   +8 more
doaj   +1 more source