Results 51 to 60 of about 183,878 (231)

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Development of a Dual Photoacoustic–Ultrasound Imaging System: Current Status and Future Perspectives

Sensors
Integrated photoacoustic and ultrasound (PAUS) imaging is a promising technology for both preclinical and clinical applications, as it exploits both advantages of photoacoustic (PA) and ultrasound (US) imaging in high resolutions and acoustic penetration
Van Hiep Pham, Tuan Nguyen Van
doaj   +1 more source

DSG2+ Cancer Stem Cells Co‐Located With FAP+ Myofibroblasts in the Tumor Boundary That Determines the Efficacy of Immunotherapy in Non‐Small Cell Lung Cancer

Advanced Science, EarlyView.
Cancer stem cells (CSCs) in non‐small cell lung cancer display pronounced plasticity and spatial heterogeneity. By integrating single‐cell and spatial transcriptomics, this study defines a DSG2‐associated CSC program and reveals a tumor‐margin niche formed with FAP+ myofibroblasts.
Guangyu Fan, Le Tang, Tongji Xie, Mengwei Yang, Lin Li, Sheng Yang, Puyuan Xing, Xiaohong Han, Yuankai Shi   +8 more
wiley   +1 more source

Structure‐Guided Engineering of a Cas12i Nuclease Unlocks Near‐PAMless Genome Editing

Advanced Science, EarlyView.
CRISPR‐Cas nucleases are limited by PAM requirements, restricting genome accessibility. Structure‐guided engineering of the compact Cas12i nuclease SF01 produced three variants with near‐PAMless, enabling efficient editing at diverse 5'‐NNTN‐3' sites. These nucleases expand the editable portion of the human genome more than fourfold, enabling efficient
Qitong Chen, Hanlin Gou, Chao Xu, Sihan Wang, Huitao Zhang, Minglei Song, Mengge Wang, Xingkun Ji, Xiaofei Wei, Yuanyan Tan, Hehua Quan, Pengyu Luo, Hanyu Shou, Pengpeng Liu, Yafeng Liang, Jian‐Kang Zhu   +15 more
wiley   +1 more source

The Role of Courts in International Arbitration: A Critical Assessment on the Arbitration Draft Bill in Iran from the Perspective of Modern Arbitration Rules [PDF]

Faṣlnāmah-i Pizhūhish-i Huqūq-i Khuṣūṣī, 2018
The role of courts in international arbitration can scarcely be denied. Courts play a crucial role in different stages in international arbitration. Having said that, the extent of courts' intervention in international arbitration has been subject to ...
Ali Moghaddam Abrishami, Masoud Mahboub
doaj   +1 more source

TRAC Variants Associate with IgA Nephropathy [PDF]

Journal of the American Society of Nephrology, 2009
The T cell receptor alpha constant gene (TRAC) encodes the constant region of the alpha chain for the T cell receptor, and the association of its gene variants with IgA nephropathy remains controversial. The authors resequenced the gene in 100 patients with IgA nephropathy and 100 controls, tested its linkage disequilibrium pattern, constructed ...
Lou, T, Vyse, TJ, Xue, C, Lam, MF, Zhang, J, Li, C, Huang, W, Li, Y, Tao, Y, Li, R, Wang, Y, Wu, C, Lai, KN, Leung, JCK   +13 more
openaire   +4 more sources

Reionization on Large Scales I: A Parametric Model Constructed from Radiation-Hydrodynamic Simulations

, 2012
We present a new method for modeling inhomogeneous cosmic reionization on large scales. Utilizing high-resolution radiation-hydrodynamic simulations with 2048^3 dark matter particles, 2048^3 gas cells, and 17 billion adaptive rays in a L = 100 Mpc/h box,
Battaglia, Nick, Cen, Renyue, Loeb, Abraham, Trac, Hy   +3 more
core   +1 more source

Translational and Rotational Arrow Cues (TRAC) Navigation Method for Manual Alignment Tasks

ACM Transactions on Applied Perception, 2020
Many tasks in image-guided surgery require a clinician to manually position an instrument in space, with respect to a patient, with five or six degrees of freedom (DOF).
David E. Usevitch, Adam J. Sperry, J. Abbott   +2 more
semanticscholar   +1 more source

Mechanical Strain‐Programmed SDC1+ Sheath Fibroblasts Trigger CXCR4hi Neutrophil‐Mediated Enthesitis in Ankylosing Spondylitis

Advanced Science, EarlyView.
In ankylosing spondylitis (AS), mechanical strain‐programmed SDC1+ sheath fibroblasts secrete CXCL5 to recruit neutrophils and promote the activation of CXCR4hi neutrophils, thereby exacerbating enthesitis by promoting neutrophil extracellular traps (NETs) formation. SOX5 controls the generation of SDC1+ sheath fibroblasts via super‐enhancers.
Jiajie Lin, Zepeng Su, Yipeng Zeng, Yi Zhou, Chenying Zeng, Weihao Zhang, Qibo Li, Zipeng Xiao, Zibin Chen, Ziqian Liu, Yangfeng Lin, Guan Zheng, Wenhui Yu, Zhongyu Xie   +13 more
wiley   +1 more source

Task-Driven Dictionary Learning for Hyperspectral Image Classification with Structured Sparsity Constraints

, 2015
Sparse representation models a signal as a linear combination of a small number of dictionary atoms. As a generative model, it requires the dictionary to be highly redundant in order to ensure both a stable high sparsity level and a low reconstruction ...
Nasrabadi, Nasser M., Sun, Xiaoxia, Tran, Trac D.   +2 more
core   +1 more source