Results 71 to 80 of about 183,878 (231)

Therapeutic Gene Editing: DNA Repair Pathways, Emerging Editors, and Clinical Progress

iNew Medicine, EarlyView.
ABSTRACT The field of gene editing has evolved rapidly over the past decade, progressing from programmable zinc‐finger nucleases (ZFNs) and transcription activator‐like effector nucleases (TALENs) to the widespread adoption of CRISPR‐Cas systems. First‐generation editors catalyzed genome engineering by introducing targeted double‐strand breaks (DSBs ...
Li‐Kuang Tsai, Youcai Xiong, Dongqi Liu, Dongshan Yang, Jifeng Zhang, Jie Xu, Renzhi Han, Y. Eugene Chen   +7 more
wiley   +1 more source

Trustworthy repositories: Audit and certification (TRAC) Cline Library internal audit, spring 2014 [PDF]

, 2014
Audit and Certification of Trustworthy Digital Repositories (TRAC) is a recommended practice developed by the Consultative Committee for Space Data Systems.
Phillips, Kelly, Welch, Todd
core  

CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling

Med Research, EarlyView.
CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li, Peixin Huang, Yue Qian, Anqi Lin, Jingjun He, Junyi Shen, Li Chen, Kai Miao, Jian Zhang   +8 more
wiley   +1 more source

Divergent Evolution of TRC Genes in Mammalian Niche Adaptation

Frontiers in Immunology, 2019
Mammals inhabit a wide variety of ecological niches, which in turn can be affected by various ecological factors, especially in relation to immunity. The canonical TRC repertoire (TRAC, TRBC, TRGC, and TRDC) codes C regions of T cell receptor chains that
Zepeng Zhang, Yuan Mu, Lei Shan, Di Sun, Weijian Guo, Zhenpeng Yu, Ran Tian, Shixia Xu, Guang Yang   +8 more
doaj   +1 more source

Adjuvant sunitinib in patients with high-risk renal cell carcinoma: safety, therapy management, and patient-reported outcomes in the S-TRAC trial

Annals of Oncology, 2018
Background Adjuvant sunitinib has significantly improved disease-free survival versus placebo in patients with renal cell carcinoma at high risk of recurrence post-nephrectomy (hazard ratio 0.76; 95% confidence interval, 0.59–0.98; two-sided P = 0.03 ...
M. Staehler, R. Motzer, D. George, H. Pandha, F. Donskov, B. Escudier, A. Pantuck, A. Patel, L. DeAnnuntis, H. Bhattacharyya, K. Ramaswamy, G. Zanotti, X. Lin, M. Lechuga, L. Serfass, J. Paty, A. Ravaud   +16 more
semanticscholar   +1 more source

Herbivore and mesocarnivore carcasses trigger divergent short‐term changes in soil properties

Journal of Animal Ecology, EarlyView.
Scavengers reshape nutrient cycles in soils under carrion. Compared to herbivore carcasses, smaller but longer‐lasting carnivore remains boost nutrient levels and microbial activity in dry soils. Abstract Animal corpses act as pulses of organic matter (OM) and serve a key zoogeochemical role by providing localized nutrient inputs to soils and thereby ...
Adrián Colino‐Barea, Fuensanta García‐Orenes, Zebensui Morales‐Reyes, Moisés Gonzálvez, Carlos Martínez‐Carrasco, Marcos Moleón, Daniel Redondo‐Gómez, Evan A. N. Marks, Minerva García‐Carmona, Victoria Arcenegui, José Carlos Huerta‐del‐Bosque, Adrián Orihuela‐Torres, Santiago Soliveres, Sofia Albolafio, Esther Sebastián‐González, José Antonio Sánchez‐Zapata   +15 more
wiley   +1 more source

Comparative analysis of four soil water sensors for irrigation water management

Agrosystems, Geosciences & Environment
With the increasing availability of soil water sensing technologies for irrigation management, it is essential to compare sensor options in production field settings.
Rehnuma Maisha, Dean D. Steele, Aaron L. M. Daigh, Xinhua Jia, Thomas DeSutter, Christopher M. U. Neale   +5 more
doaj   +1 more source

A reappraisal of the Middle to Later Stone Age prehistory of Morocco Réévaluer la préhistoire du Maroc, du Middle Stone Age au Later Stone Age

Journal of the Royal Anthropological Institute, EarlyView.
Over the last 25 years, perceptions of the early prehistory of Northwest Africa have undergone radical changes due to new fieldwork projects and a corresponding growth in scientific interest in the region. Much of this work has been focused in Morocco, known for its extremely rich fossil and archaeological records in caves and rock shelters.
Nick Barton, Abdeljalil Bouzouggar, Stacy Carolin, Louise Humphrey   +3 more
wiley   +1 more source

CloudMonitor: Profiling Power Usage

, 2012
In Cloud Computing platforms the addition of hardware monitoring devices to gather power usage data can be impractical or uneconomical due to the large number of machines to be metered.
Khajeh-Hosseini, Ali, Smith, James William, Sommerville, Ian, Ward, Jonathan Stuart   +3 more
core   +1 more source

125 years of exploration and research at Gough's Cave (Somerset, UK) 125 ans d'exploration et de recherches à Gough's Cave (Somerset, Royaume‐Uni)

Journal of the Royal Anthropological Institute, EarlyView.
Our understanding of the recolonization of northwest Europe in the period leading up to the Lateglacial Interstadial relies heavily on discoveries from Gough's Cave (Somerset, UK). Gough's Cave is the richest Late Upper Palaeolithic site in the British Isles, yielding an exceptional array of human remains, stone and organic artefacts, and butchered ...
Silvia M. Bello, Mark D. Lewis, Simon A. Parfitt   +2 more
wiley   +1 more source