Results 41 to 50 of about 4,967,635 (422)

The systematic review and meta-analysis of X-ray detective rate of Kashin-Beck disease from 1992 to 2016

BMC Musculoskeletal Disorders, 2019
Background Kashin-Beck disease (KBD) is a serious human endemic chronic osteochondral disease. However, quantitative syntheses of X-ray detective rate studies for KBD are rare.
Xi Wang, Yujie Ning, Amin Liu, Xin Qi, Meidan Liu, Pan Zhang, Xiong Guo   +6 more
doaj   +1 more source

Integrating genome-wide DNA methylation and mRNA expression profiles identified different molecular features between Kashin-Beck disease and primary osteoarthritis

Arthritis Research & Therapy, 2018
Background Kashin-Beck disease (KBD) is an endemic osteochondropathy of unknown etiology. Osteoarthritis (OA) is a form of degenerative joint disease sharing similar clinical manifestations and pathological changes to articular cartilage with KBD ...
Yan Wen, Ping Li, Jingcan Hao, Chen Duan, Jing Han, Awen He, Yanan Du, Li Liu, Xiao Liang, Feng Zhang, Xiong Guo   +10 more
doaj   +1 more source

Association between herpes simplex virus 1 exposure and the risk of depression in UK Biobank

Clinical and Translational Medicine, 2020
Background Herpes simplex virus‐1 (HSV‐1) infection is reported to be associated with depression. But limited efforts were made to investigate the relationship between HSV‐1 infection and the risk of depression, especially from the genetic perspective ...
Jing Ye, Yan Wen, Xiaomeng Chu, Ping Li, Bolun Cheng, Shiqiang Cheng, Li Liu, Lu Zhang, Mei Ma, Xin Qi, Chujun Liang, Om Prakash Kafle, Yumeng Jia, Cuiyan Wu, Sen Wang, Xi Wang, Yujie Ning, Feng Zhang   +17 more
doaj   +1 more source

Abnormal expression of TSG-6 disturbs extracellular matrix homeostasis in chondrocytes from endemic osteoarthritis

Frontiers in Genetics, 2022
Background and aims: Kashin-Beck disease (KBD) is a unique endemic osteochondropathy with unclear pathogenesis in China. T-2 toxin exposure has been identified as a significant risk factor of KBD.
Yujie Ning, Pan Zhang, Feiyu Zhang, Sijie Chen, Yanli Liu, Feihong Chen, Yifan Wu, Shujin Li, Chaowei Wang, Yi Gong, Minhan Hu, Ruitian Huang, Hongmou Zhao, Xiong Guo, Xiong Guo, Xi Wang, Lei Yang   +16 more
doaj   +1 more source

A global database for plants that hyperaccumulate metal and metalloid trace elements.

New Phytologist, 2018
Hyperaccumulators are unusual plants that accumulate particular metals or metalloids in their living tissues to levels that may be hundreds or thousands of times greater than is normal for most plants (Reeves, 2003; van der Ent et al., 2013 ...
R. Reeves, A. Baker, T. Jaffré, P. Erskine, G. Echevarria, A. van der Ent   +5 more
semanticscholar   +1 more source

A large-scale polygenic risk score analysis identified candidate proteins associated with anxiety, depression and neuroticism

Molecular Brain, 2022
Psychiatric disorders and neuroticism are closely associated with central nervous system, whose proper functioning depends on efficient protein renewal. This study aims to systematically analyze the association between anxiety / depression / neuroticism ...
Bolun Cheng, Xuena Yang, Shiqiang Cheng, Chun’e Li, Huijie Zhang, Li Liu, Peilin Meng, Yumeng Jia, Yan Wen, Feng Zhang   +9 more
doaj   +1 more source

Bedrock and soil geochemistry influence the content of chemical elements in wild edible mushrooms (Morchella group) from South Italy (Sicily) [PDF]

, 2019
Chemical elements in the samples of wild edible mushrooms of the Morchellagroup collected from different unpolluted Sicilian sites was analyzed by the ICP-MS (method) to detect the content of their minerals and determine whether soil geology and ...
Alessandro Saitta, Elia Ambrosio, Maria Grazia Alaimo   +2 more
core   +1 more source

Evaluating the genetic effects of sex hormone traits on the development of mental traits: a polygenic score analysis and gene-environment-wide interaction study in UK Biobank cohort

Molecular Brain, 2021
Objective To evaluate the genetic effects of sex hormone traits on the development of mental traits in middle-aged adults. Methods The SNPs associated with sex hormone traits were derived from a two-stage genome-wide association study (GWAS).
Xiao Liang, ShiQiang Cheng, Jing Ye, XiaoMeng Chu, Yan Wen, Li Liu, Xin Qi, YuMeng Jia, Feng Zhang   +8 more
doaj   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

FEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Theo Crawford, Sassan Rahnama, Eivind A. B. Undheim, Irina Vetter, Yanni K. ‐Y. Chin, Mehdi Mobli   +8 more
wiley   +1 more source

Gut microbiota is associated with bone mineral density: an observational and genome-wide environmental interaction analysis in the UK Biobank cohort

Bone & Joint Research, 2021
Aims: Despite the interest in the association of gut microbiota with bone health, limited population-based studies of gut microbiota and bone mineral density (BMD) have been made.
Bolun Cheng, Yan Wen, Xuena Yang, Shiqiang Cheng, Li Liu, Xiaomeng Chu, Jing Ye, Chujun Liang, Yao Yao, Yumeng Jia, Feng Zhang   +10 more
doaj   +1 more source