Results 151 to 160 of about 82,913 (307)

Resolving Endoplasmic Reticulum‐Protein Misfolding Restores Corticosteroid Sensitivity in Experimental Models of Severe Asthma

open access: yesAllergy, EarlyView.
This study investigates the role of ER stress in steroid resistance in severe asthma. Results from advanced 3D models of human bronchial epithelial cells, steroid‐resistant severe asthma mouse models, and human severe asthma sputum samples show that treatment with ICS in combination with the ER stress inhibitor 4‐PBA significantly enhances steroid ...
Prabuddha S. Pathinayake   +8 more
wiley   +1 more source

Peri‐operative fasting in adults: an international, multidisciplinary consensus statement

open access: yesAnaesthesia, EarlyView.
Summary Introduction Evidence suggests that existing pre‐operative fasting guidelines are associated with prolonged fasting times. Prolonged fasting, particularly from clear liquids, has the potential to harm patients through reduced peri‐operative wellbeing; impaired glucose metabolism and peri‐operative inflammatory response; delayed return of bowel ...
Anne Rüggeberg   +67 more
wiley   +1 more source

Evaluation of a Rat Cardiopulmonary Bypass Model Using an Extraluminal Flow Oxygenator

open access: yesArtificial Organs, EarlyView.
A rat cardiopulmonary bypass model was constructed incorporating the developed extraluminal flow oxygenator and compared with a commercial intraluminal flow oxygenator. Both oxygenators demonstrated comparable gas exchange performance and inflammatory responses; however, the one developed in this study better preserved PLT counts.
Hirohito Sumikura   +3 more
wiley   +1 more source

Hormonal Treatment During Ex Vivo Lung Perfusion Ameliorates Brain Death Induced Inflammation

open access: yesArtificial Organs, EarlyView.
Treatment of lungs during ex vivo perfusion with 17β‐estradiol and methylprednisolone improved graft quality. In females, treated and non‐treated groups presented reduced leukocyte infiltration and only the treatment improved perfusion flow. In males, treatment improved lung function by increasing compliance, paO2, and perfusion flow.
Marina Vidal‐dos‐Santos   +9 more
wiley   +1 more source

Impact of Gentamicin‐Impregnated Collagen Sponge on the Incidence of Access Related Infections After Full‐Support Microaxial Flow Pump Therapy

open access: yesArtificial Organs, EarlyView.
Local application of gentamicin for wound closure after full‐support microaxial flow pump therapy. ABSTRACT Background Surgically implanted microaxial flow pumps (mAFP) are increasingly used for cardiogenic shock treatment. Standard mAFP explantation is performed bedside with a shortening of the vascular prosthesis, which may represent a potential ...
Gaik Nersesian   +11 more
wiley   +1 more source

Risk Factors for Airway Infantile Hemangioma

open access: yesActa Paediatrica, EarlyView.
ABSTRACT Aim An infantile hemangioma (IH) affecting the airway is rare. Identifying infants at risk for an airway IH is crucial to avoid potential airway compromise. Our objective was to identify risk factors for an airway IH and to study its incidence and treatments.
Eeva Castrén   +2 more
wiley   +1 more source

CLINICO–Demographic Profile and Outcomes of Hospitalised Children With Diphtheria in A Tertiary Care Hospital of Peshawar

open access: yesActa Paediatrica, EarlyView.
ABSTRACT Aim To determine the clinico‐demographic profile and predictors of mortality in hospitalised children with diphtheria. Methods This retrospective cohort study included 202 children aged 5–16 years diagnosed with diphtheria per WHO criteria at Lady Reading Hospital, Peshawar, from January 2023 to December 2024. Data on demographics, vaccination
Amir Muhammad   +6 more
wiley   +1 more source

Oral Health Care Services, Barriers and Enablers to Maintaining Good Oral Health in Motor Neurone Disease: A Scoping Review

open access: yesCommunity Dentistry and Oral Epidemiology, EarlyView.
ABSTRACT Objectives The objective of this scoping review was to map existing literature on oral health and related care in individuals with Motor Neurone Disease (MND). Specifically, the review aimed to identify barriers and facilitators to maintaining oral hygiene, summarise available clinical guidelines and patient‐facing resources, and examine how ...
Mariam A. Khokhar   +3 more
wiley   +1 more source

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