Results 31 to 40 of about 27,112 (242)

Cognitive and Neuroimaging Divergence Between Juvenile and Adult FUS Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive motor neuron degeneration. Fused in sarcoma (FUS)‐associated juvenile ALS (jALS) represents a distinct and aggressive subgroup with rapid deterioration and poor prognosis.
Alexandra V. Jürs, Marcel Naumann, Annaliis Lehto, Hanna Schön, Jens Kurth, Johannes Prudlo, Andreas Hermann, Elisabeth Kasper   +7 more
wiley   +1 more source

Tracheotomy: clinical review and guidelines

, 2007
Tracheotomy is a commonly performed procedure. The Belgian Society of Pneumology (BVP-SBP) and the Belgian Association for Cardiothoracic Surgery (BACTS) developed guidelines on tracheotomy for mechanical ventilation in adults.
Paul Van Schil, Depuydt, Pieter, Van Meerhaeghe, Alain, Youri Sokolov, Marion Delcroix, Pieter Depuydt, De Leyn, Paul, VAN MEERHAEGHE, A, Bedert, Lieven, VAN SCHIL, P, Van Schil, Paul, DELCROIX, M, SOKOLOV, Y, Lieven Bedert, Delcroix, Marion, Sokolow, Youri, Sokolov, Youri, Geert Lauwers, DE LEYN, P, BEDERT, L, Alain Van Meerhaeghe, Lauwers, Geert, LAUWERS, G, Paul De Leyn   +23 more
core   +1 more source

Lactiplantibacillus Plantarum GUANKE Alleviates Allergic Asthma by Restricting Monocyte‐to‐DC Differentiation Via Microbiota‐Associated IAA

Advanced Science, EarlyView.
Lactiplantibacillus plantarum GUANKE remodels the indigenous gut microbiota and is associated with microbiota‐dependent restoration of circulating IAA. IAA treatment attenuates JAK3‐STAT3 and Jag1‐Notch4‐Hey1 signaling and reduces CX3CR1+Ly6C− monocytic precursor generation and pulmonary CD11b+ DC accumulation, together with reduced Th2 inflammation ...
Yujia He, Jielan Mi, Zhiping Zhao, Xiao Zhang, Zhihan Yang, Kun Yue, Yuanming Huang, Liqiong Song, Xiaoting Wen, Jianguo Xu, Zhihong Ren   +10 more
wiley   +1 more source

Tracheotomy in the intensive care unit: guidelines from a French expert panel

Annals of Intensive Care, 2018
Tracheotomy is widely used in intensive care units, albeit with great disparities between medical teams in terms of frequency and modality. Indications and techniques are, however, associated with variable levels of evidence based on inhomogeneous or ...
Jean Louis Trouillet, Olivier Collange, Fouad Belafia, François Blot, Gilles Capellier, Eric Cesareo, Jean-Michel Constantin, Alexandre Demoule, Jean-Luc Diehl, Pierre-Grégoire Guinot, Franck Jegoux, Erwan L’Her, Charles-Edouard Luyt, Yazine Mahjoub, Julien Mayaux, Hervé Quintard, François Ravat, Sebastien Vergez, Julien Amour, Max Guillot   +19 more
doaj   +1 more source

Tracheotomy in ICU

, 2018
International audienceTracheotomy is widely used in intensive care units, albeit with great disparities between medical teams in terms of frequency and modality.
Mahjoub, Yazine, Constantin, Jean-Michel, Jegoux, Franck, Trouillet, Jean-Louis, Amour, Julien, Mayaux, Julien, Capellier, Gilles, Luyt, Charles-Edouard, Cesareo, Eric, Collange, Olivier, Belafia, Fouad, Guinot, Pierre-Gregoire, Ravat, Francois, Demoule, Alexandre, Vergez, Sebastien, Diehl, Jean-Luc, Blot, Francois, L'Her, Erwan, Guillot, Max, Quintard, Herve   +19 more
core   +1 more source

Smartphone‐Guided Visible Light Modulation of RSNOs for Antimicrobial Activity via Controlled Nitric Oxide Release

Advanced Science, EarlyView.
A light‐activated catheter insert combines antimicrobial blue light with nitric oxide release to generate complementary oxidative and nitrosative stress, producing potent broad‐spectrum antimicrobial activity. The approach achieves greater than 4‐log reductions in bacterial and fungal viability and significantly reduces Staphylococcus aureus ...
Alexander Bruckmann, Adam Brooks Goodman, Myddelton C. Parker, Mark Garren, Ji Eun Park, Chad Schmiedt, Hitesh Handa, Elizabeth J. Brisbois   +7 more
wiley   +1 more source

Incidence, Etiology and Outcome of Ventilator-Associated Pneumonia in Patients with Percutaneous Tracheotomy

Acta Clinica Croatica, 2017
Although the incidence of ventilator-associated pneumonia (VAP) is very high, there are still many uncertainties about clinical course of VAP among tracheotomized patients.
Tihana Magdić Turković, Melanija Obraz, Milana Zlatić Glogoški, Ida Juranić, Bruna Bodulica, Josipa Kovačić   +5 more
doaj   +1 more source

ACAT1‐Mediated SP1‐K694 Lactylation Promotes M1 Macrophage Polarization via TREM1 Transcription in COPD

Advanced Science, EarlyView.
Upon cigarette smoke exposure(CSE), LDHA expression is increased in lung macrophages, promoting the conversion of pyruvate to lactate and elevating the lactylation level of SP1 at the K694 site. This, in turn, enhances SP1 enrichment at the TREM1 promoter, increases TREM1 expression, promoted M1 macrophage polarization, and triggers the secretion of ...
Ling Lin, Ping Zhang, Qing Song, Tao Li, Yuqin Zeng, Ping Chen   +5 more
wiley   +1 more source

Pediatric tracheotomy: Results of a single center study on 46 patients

Medicine Science, 2022
In this study, we aimed to present our tracheotomy experiences in pediatric patients in our hospital. We reviewed the data by analyzing pediatric tracheotomy retrospectively in terms of indications, follow-up and complications.
Mehmet Tan, Emrah Gunduz, Hatice Celik, Tuba Bayindir   +3 more
doaj   +1 more source

LAPTM5 Downregulation‐Driven VAMP8 Phosphorylation Impairs Autophagosome‐Lysosome Fusion and Aggravates Septic Acute Lung Injury

Advanced Science, EarlyView.
LAPTM5 functions as a critical molecular scaffold bridging PGAM5 and VAMP to facilitate PGAM5‐mediated dephosphorylation of VAMP8. This cascade promotes autophagosome‐lysosome fusion, restores impaired autophagic flux, and clears damaged mitochondria, thereby mitigating cellular oxidative stress and systemic inflammation.
Lang Jiang, Qilan Li, Hao Liu, Xuehui Gao, Hongyu Nie, Lang Chen, Mei He, Xuefeng Li, Xiangming Fang, Jiqian Xu, Hao Zhang, Jiahong Xia, You Shang   +12 more
wiley   +1 more source