Simultaneous lineage tracing and cell-type identification using CRISPR/Cas9-induced genetic scars
Nature Biotechnology, 2018 A key goal of developmental biology is to understand how a single cell is transformed into a full-grown organism comprising many different cell types.
B. Spanjaard +6 more
semanticscholar +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Research on the Cultural Tracing of the Patriarchal Clan System of Traditional Buildings in the Eastern Zhejiang Province, China, Based on Space Syntax: The Case Study of Huzhai in Shaoxing [PDF]
, 2022 Xiaoxiao Rao +5 more
openalex +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Factors Influencing the Adoption of Contact Tracing Applications: Protocol for a Systematic Review [PDF]
, 2021 Kiemute Oyibo +3 more
openalex +1 more source
Genetic lineage tracing defines myofibroblast origin and function in the injured heart
Nature Communications, 2016 Cardiac fibroblasts convert to myofibroblasts with injury to mediate healing after acute myocardial infarction (MI) and to mediate long-standing fibrosis with chronic disease. Myofibroblasts remain a poorly defined cell type in terms of their origins and
Onur Kanisicak +10 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley +1 more source
Tracing IgE-Producing Cells in Allergic Patients
Cells, 2019 Immunoglobulin E (IgE) is the key immunoglobulin in the pathogenesis of IgE associated allergic diseases affecting 30% of the world population. Recent data suggest that allergen-specific IgE levels in serum of allergic patients are sustained by two ...
Julia Eckl-Dorna +11 more
doaj +1 more source
Study of lower hybrid wave propagation in ionized gas by Hamiltonian theory
, 2013 In order to find an approximate solution to the Vlasov-Maxwell equation system describing the lower hybrid wave propagation in magnetic confined plasmas, the use of the WKB method leads to the ray tracing equations.
Cardinali, Alessandro, Casolari, Andrea
core +1 more source