Railway Substructure Modeling Approach for Modal Analysis Using Multibody Simulation
A novel modeling solution (MS) was created that can provide realistically accurate results on the natural frequencies of a railway subgrade layer in the context of a railway infrastructure numerical simulation.
João Morais +3 more
doaj +1 more source
THE KINEMATIC ANALYSIS OF THE GRAB, REAR TRACK AND FRONT TRACK START IN SWIMMING [PDF]
The aim of this study was to determine the differences in the kinematic parameters between the grab and track starts (rear-weighted track and front-weighted track).
Bergun Meric Bingul +3 more
doaj
Discerning protein pools by selective staining with self‐labeling tags
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Ecological Footprint Analysis of Tramway Track Structures
The European urban landscape has been constantly evolving in the last 70 years since the Second World War. Thus, European cities are developing their own public transport networks.
Zoltán Major +3 more
doaj
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Development of a new design methodology for slab track systems
Owing to the rapid increase in the demands of train speed and axle loads, the slab track has been introduced to replace the ballast in the classical ballasted track with reinforced concrete slab or asphalt-bearing layer to improve the track stability ...
Mohamed Hafez Aly +3 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Terrestrial Laser Scanning as a Part of Railway Comprehensive Diagnostics
A comprehensive diagnosis of the railway line aims to control its actual structure and geometric arrangement. Such railway inspections can help detect potential track deformation caused by operational loads and climatic effects.
Jana Izvoltova +3 more
doaj +1 more source
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source

