Results 101 to 110 of about 686,506 (283)

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

open access: yesFEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima   +7 more
wiley   +1 more source

Tracking Down the Business Cycle

open access: yes, 2007
We use a Bayesian dynamic factor model to measure Germany’s pre World War I economic activity. The procedure makes better use of existing time series data than historical national accounting. To investigate industrialization we propose to look at comovement between sectors.
Sarferaz, Samad, Uebele, Martin
openaire   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

open access: yesAging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Relationship between upper extremity fat mass and race time in triathlete

open access: yesTürk Spor ve Egzersiz Dergisi, 2017
This study was conducted to investigate the effect of upper extremity fat ratio on triathletes’ the race time. 43 volunteer athletes who participated in the 9th World University Triathlon Championship ((17 women – 26 men), age 22.30 ± 2.42 years, height ...
Ebru Cetın   +4 more
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

open access: yesAging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Evaluation of a Chlamydia trachomatis-specific, commercial, real-time PCR for use with ocular swabs

open access: yesParasites & Vectors, 2018
Background Trachoma, the leading infectious cause of blindness worldwide, is caused by conjunctival Chlamydia trachomatis infection. Trachoma is diagnosed clinically by observation of conjunctival inflammation and/or scarring; however, there is evidence ...
Harry Pickering   +4 more
doaj   +1 more source

Self‐Regulated Learning Meets AI: Reinterpreting Self‐Regulation, Co‐Regulation, and Socially Shared Regulation in Human–AI Interaction

open access: yesNew Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Advancing artificial intelligence (AI) has transformed learning and work, yet higher education and professional development programs have not systematically equipped learners for AI‐prevalent environments. This lack of preparation creates uncertainty regarding control, responsibility, trust, and accountability.
Moon‐Heum Cho, Jerusalem Merkebu
wiley   +1 more source

Too close for cycling comfort? Social and physical contributors to subjective cycling safety in the context of overtaking: Results from a mixed-methods study combining data from OpenBikeSensors, the SimRa app, and qualitative interviews

open access: yesJournal of Urban Mobility
Cycling is a central component of the mobility transition towards a sustainable mobility culture. While existing research on cycling largely focuses on transport infrastructure, the influence of subjective safety as a key factor in the decision to cycle ...
Jennifer Bosen   +3 more
doaj   +1 more source

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