Results 51 to 60 of about 34,348 (252)
Integration of Genetic Algorithm and Support Vector Machine to Predict Rail Track Degradation
MATEC Web of Conferences, 2019 Gradual deviation in track gauge of tram systems resulted from tram traffic is unavoidable. Tram gauge deviation is considered as an important parameter in poor ride quality and the risk of train derailment.
Falamarzi Amir +3 more
doaj +1 more source
PERSPECTIVES OF UKRAINIAN RAILWAY TOURISM DEVELOPMENT ON NARROW-GAUGE LINES OF ZAKARPATTIA
Nauka ta progres transportu, 2015 Purpose.The purpose of the paper is: (1) the definition of perspectives development of Ukrainian railway tourism on the narrow gauge lines of Zakarpattia; 2) technical condition analysis of Borzhava narrow gauge railway for the project to restore the ...
V. G. Kuznetsov +4 more
doaj +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
An Eye-Tracking Evaluation of Gauge Shapes in Process Control [PDF]
Proceedings of the Human Factors and Ergonomics Society Annual Meeting, 2019 Operators monitor gauge shapes in control room displays to maintain the status of the refinery control process within normal limits. To test if shapes currently used by operators are effectively designed, two experiments were conducted to test the effectiveness of individual shapes in a Visual Thesaurus toolkit for comprehension and change detection ...
Chao Shi, Ling Rothrock
openaire +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Technical requirements for acceptance of works on track [PDF]
Tehnika, 2020 This paper presents technical requirements for acceptance of track works according to European standard EN 13231-1, which was adopted as Serbian standard in 2014.
Popović Zdenka J. +3 more
doaj
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source