Results 61 to 70 of about 567,851 (266)
Translating whole‐genome doubling into precision medicine in cancer
Molecular Oncology, EarlyView.Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
The impacts of intellectual capital of microfinance institutions on poverty alleviation
Ho Chi Minh City Open University Journal of Science - Economics and Business AdministrationThis study examines the impact of Intellectual Capital (IC) on poverty alleviation using a panel dataset of 3,114 Microfinance Institutions (MFIs) across 120 countries from 2009 - 2018.
Chi Tung Luong +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
Retail SMEs' performance under impacts of technological uncertainty [PDF]
Innovation & Management ReviewPurposeThe study aims to clarify the impact of technological uncertainty (TU) on emerging market retail SMEs' performance with the mediating roles of digital capabilities (DCs) and marketing innovation capability (MarIC).Design/methodology/approachThe ...
Hoang Van Dinh +3 more
doaj +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source
Tạp chí Khoa học Đại học Đà LạtThe purpose of this study is twofold. First, we attempt to quantify the quality of bank sustainability reporting (QSR) since the 2016 mandatory sustainability disclosure in Vietnam. Content analysis of banks’ annual reports is performed to assess 11 QSR
Van Ha Nguyen +2 more
doaj +1 more source
Transport accessibility as factor of excursion tourism development (case of Chernivtsi, Ukraine)
Časopis Socìalʹno-Ekonomìčnoï Geografìï. Часопис соціально-економічної географії, 2016 In the course of scientific research found that for parameterization of complex socio-economic processes with the use of transport infrastructure in tourism advisable to use transport accessibility ratio (the ratio of current and potential routes) with ...
Roman Hyshchuk, Olexandra Pylypets'
doaj +1 more source