Results 41 to 50 of about 2,379,016 (300)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Physical and Monetary Methods for Estimating the Hidden Trade of Materials

Resources, 2019
The hidden trade of a material (e.g., aluminum) refers to the trade of that material embedded in final products (e.g., automobiles). There are two methods for estimating the hidden trade amount of materials: (1) the physical method relies on the physical
Wei-Qiang Chen, Zi-Jie Ma, Stefan Pauliuk, Tao Wang   +3 more
doaj   +1 more source

Tools of the trade: theory and method in mindfulness neuroscience [PDF]

Social Cognitive and Affective Neuroscience, 2012
Mindfulness neuroscience is an emerging research field that investigates the underlying mechanisms of different mindfulness practices, different stages and different states of practice as well as different effects of practice over the lifespan. Mindfulness neuroscience research integrates theory and methods from eastern contemplative traditions ...
Yi-Yuan, Tang, Michael I, Posner
openaire   +2 more sources

The mystery of misreported trade: A novel method to identify distorted trade figures

The World Economy, 2023
AbstractThis research shows that misreporting of trade is rampant, which markedly reduces the quality of reported bilateral trade data. We devise a novel methodology to correct for misreported bilateral trade while accounting for the composition of product types and for trading partners.
Mohammad Farhad, Jakob B. Madsen, Michael Jetter, Andrew Williams   +3 more
openaire   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Trade liberalization and child mortality: A Synthetic Control Method [PDF]

World Development, 2017
Abstract We study the effect of trade liberalization on child mortality using data from emerging and developing countries over the 1960–2010 period. To capture possible heterogeneity of effects, we use the Synthetic Control Method (SCM) for comparative case studies.
Olper, Alessandro, Curzi, Daniele, Swinnen, Johan   +2 more
openaire   +3 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

U.S. trade in the sphere of strategic products and services as the first level of analysis of its economic security [PDF]

Industrija
The purpose of this research paper is to highlight the importance of the interplay between trade and economic performance, along with the connections among U.S. trade in critical goods and services and its economic security. The scientific paper seeks to
Todorović Marina
doaj   +1 more source

Methods of Assessing Efficiency of Intangible Resources in E-Trade

Вестник Российского экономического университета имени Г. В. Плеханова, 2022
The article underlines a leading role of intangible resources and assets in overall reserves of e-trade organization. Due to the fact that e-trade of entities using intangible resources have certain specific features affecting reliability of efficiency ...
A. F. Nikishin, E. A. Mayorova, O. S. Karashсhuk   +2 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source