Results 41 to 50 of about 256,091 (263)

Trading in Markovian Price Models [PDF]

, 2005
We examine a Markovian model for the price evolution of a stock, in which the probability of local upward or downward movement is arbitrarily dependent on the current price itself (and perhaps some auxiliary state information). This model directly and considerably generalizes many of the most well-studied price evolution models in classical finance ...
Sham M. Kakade, Michael J. Kearns
openaire   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Ancient Maya economics: models, markets, and trade routes

Frontiers in Human Dynamics
Research in the Maya area has now generated sufficient archeological data to better define past economic systems. Our traditional understanding of the ancient Maya was largely driven by archeological finds related to the elite stratum of society and by ...
Arlen F. Chase, Diane Z. Chase, Adrian S. Z. Chase   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Quantifying the Health–Economy Trade-Offs: Mathematical Model of COVID-19 Pandemic Dynamics

Computation
The COVID-19 pandemic has presented a complex situation that requires a balance between control measures like lockdowns and easing restrictions. Control measures can limit the spread of the virus but can also cause economic and social issues.
Dhika Surya Pangestu, Sukono, Nursanti Anggriani, Najib Majdi Yaacob   +3 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

The non-linear nature of the cost of comprehensibility

Journal of Big Data, 2022
A key challenge in Artificial Intelligence (AI) has been the potential trade-off between the accuracy and comprehensibility of machine learning models, as that also relates to their safe and trusted adoption. While there has been a lot of talk about this
Sofie Goethals, David Martens, Theodoros Evgeniou   +2 more
doaj   +1 more source

Optimization of trading physics models of markets [PDF]

IEEE Transactions on Neural Networks, 2000
We describe an end-to-end real-time S&P futures trading system. Inner-shell stochastic nonlinear dynamic models are developed, and Canonical Momenta Indicators (CMI) are derived from a fitted Lagrangian used by outer-shell trading models dependent on these indicators.
Lester Ingber, Radu Paul Mondescu
openaire   +4 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Bilateral Trade Flows and Income Distribution Similarity. [PDF]

PLoS ONE, 2016
Current models of bilateral trade neglect the effects of income distribution. This paper addresses the issue by accounting for non-homothetic consumer preferences and hence investigating the role of income distribution in the context of the gravity model
Inmaculada Martínez-Zarzoso, Sebastian Vollmer   +1 more
doaj   +1 more source