Results 41 to 50 of about 1,414,584 (301)

On the energy efficiency-spectral efficiency trade-off over the MIMO rayleigh fading channel [PDF]

open access: yes, 2012
Along with spectral efficiency (SE), energy efficiency (EE) is becoming one of the key performance evaluation criteria for communication system. These two criteria, which are conflicting, can be linked through their trade-off. The EE-SE trade-off for the
Héliot, Fabien   +2 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Leverage, entrenched managers, and moderating effect of main shareholder’s influence [PDF]

open access: yesRevista Contabilidade & Finanças
This study associated the leverage of Brazilian listed companies with their managers’ search for protection against the risk of main shareholder’s intervention.
Bruno José Canassa   +2 more
doaj   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

open access: yesMolecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris   +10 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

open access: yesMolecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang   +3 more
wiley   +1 more source

An alternative test of the trade-off theory of capital structure

open access: yesContemporary Economics, 2014
The purpose of this paper is to investigate the stochastic behavior of corporate debt ratios utilizing a balanced panel of 2,556 publicly traded U.S. firms during the period 1997-2010.
Giorgio Canarella   +2 more
doaj   +1 more source

A multi-level test of the seed number/size trade-off in two Scandinavian communities. [PDF]

open access: yesPLoS ONE, 2018
Seed size is a fundamental life-history trait for plants. A seed number/size trade-off is assumed because the resources invested in reproduction are limited; however, such a trade-off is not always observed. This could be a consequence of the method used
Amparo Lázaro, Asier R Larrinaga
doaj   +1 more source

The coronavirus trade-off – Life vs. economy: Handling the trade-off rationally and optimally

open access: yesSocial Sciences and Humanities Open, 2021
:: The recent coronavirus outbreak has made governments face an inconvenient trade-off choice, i.e. the choice between saving lives and saving the economy, forcing them to make immensely consequential decisions among alternative courses of actions ...
Ali Zeytoon-Nejad, Tanzid Hasnain
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

TRADE-OFF VERSUS PECKING ORDER THEORY IN LISTED COMPANIES AROUND THE WORLD [PDF]

open access: yesAnnals of the University of Petrosani: Economics, 2012
This paper provides an insight into the literature on capital structure and its determinants. The capital structure refers to the specific combination of debt and equity and their use in financing the corporate operations.
SORANA VĂTAVU
doaj  

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