Results 51 to 60 of about 38,481 (288)

Modifying Glucose Metabolism Reverses Memory Defects of Alzheimer's Disease Model at Late Stages

Advanced Science, EarlyView.
Using spatial transcriptomics, we show that ferul enanthate (SL‐ZF‐01) reverses episodic‐like memory deficits in aged, but not young, Alzheimer’s disease (AD) mice. SL restores glucose metabolism and Glucose Transporter 1/3 expression via an ‘Aging‐AD‐Rescue’ pattern, rescuing deficits seen in aged AD mice.
Fang Liu, Yiyu‐Li Tang, Zong‐Bo Zhang, Ya‐Hong Tan, Si‐Hui Lin, Ni‐Ya Wang, Jin‐Nan Li, Zhi‐Jie Pan, Jian‐Feng Li, Jing‐Fei Huang, Yu‐Qiang Ding, Chun‐Ming Guo, Lin Xu, Cheng Peng, Qi‐Xin Zhou   +14 more
wiley   +1 more source

Reinterpretation of the Average Consumer Benchmark considering Recent Developments

İstanbul Hukuk Mecmuası
In trademark law, the “average consumer” is a benchmark that represents the target audience of a product or service and is considered in cases of trademark registration or infringement. This criterion plays a decisive role in assessing consumer behaviour
Gül Büyükkılıç
doaj   +1 more source

The Extraterritorial Reach of Trademarks on the Internet [PDF]

, 2002
The advent of the Internet means incredible opportunity for global interaction. Consumers in Asia can buy from a small business in Louisiana, and businesses can advertise to a much wider market for a fraction of the cost of traditional media.
Simonyuk, Yelena
core   +1 more source

A Patient‐Derived Organ‐on‐Chip Platform for Modeling the Tumor Microenvironment and Drug Responses in Pancreatic Cancer

Advanced Science, EarlyView.
Researchers have developed a patient‐derived organ‐on‐a‐chip model for pancreatic cancer by integrating cancer cells with supportive stromal and immune cells inside a microfluidic device. This system mimics the tumor microenvironment, enabling personalized testing of chemotherapy and immunotherapy, and offering new insights into how targeting ...
Darbaz Adnan, Natan Roberto de Barros, Luca S. Santovito, Xuhong Cheng, Kristi M. Lawrence, Mariah K. Barnett, Martine D. Boetto, Neal Mehta, Ajaypal Singh, Lin Cheng, Xiangsheng Huang, Faraz Bishehsari   +11 more
wiley   +1 more source

Legal Protection Of Well-Known Trademarks Under Indonesian Law

Constitutionale
This research evaluates the legal protection of famous trademarks under Indonesian law, examining the extent to which existing regulations safeguard trademarks with strong public recognition.
Wiwin Windiantina, Neneng Nurastriani
doaj   +1 more source

Perlindungan Hukum Terhadap Merek Terkenal Dari Tindakan Passing Off Berdasarkan Undang-undang Nomor 15 Tahun 2001 Tentang Merek [PDF]

, 2014
Developments and advances in the field of economics, mainly trade in goods and services had a positive impact and negative for the world in the field of industrial intellectual property rights, especially in the field of trademark. The influx of economic
Firdaus, F. (Firdaus), Hendra, R. (Rahmad), Samariadi, S. (Samariadi)   +2 more
core  

Trademark Vigilance in the Twenty-First Century: An Update [PDF]

, 2020
The trademark laws impose a duty upon brand owners to be vigilant in policing their marks, lest they be subject to the defense of laches, a reduced scope of protection, or even death by genericide.
Sloane, Peter S.
core   +1 more source

CircTspan3 Promotes Cartilage Development Through ANNEXIN A2‐Mediated Ferroptosis and Apoptosis Inhibition and Exosome‐Mediated Paracrine Signaling

Advanced Science, EarlyView.
This study reveals that XBP1s drives production of circTspan3, a circular RNA that strengthens cartilage by boosting anabolic activity and limiting cell death. Phosphorylated ANXA2 directs circTspan3 into exosomes, enabling paracrine repair. Exosomal circTspan3 expands growth‐plate cartilage and promotes in vivo regeneration, highlighting its promise ...
Yiming Pan, Fengmei Zhang, Jiayan Zhong, Qian Gong, Nana Geng, Biao Kuang, Qiumei Lan, Miao Yi, Qiqi Zeng, Cheng Chen, Mengtian Fan, Chunliang Zhao, Deping Zeng, Yu Du, Mao Nie, Zhibiao Wang, Fengjin Guo   +16 more
wiley   +1 more source

A Novel Analytic Framework of Technology Mining Using the Main Path Analysis and the Decision-Making Trial and Evaluation Laboratory-Based Analytic Network Process

Mathematics, 2021
Tech mining is an analytical method of technology monitoring that can reveal technology trends in different industries. Patent databases are the major sources for information retrieval by tech mining methods.
Chi-Yo Huang, Liang-Chieh Wang, Ying-Ting Kuo, Wei-Ti Huang   +3 more
doaj   +1 more source

Mendelian Randomization and Double Machine Learning Modeling Reveal Brain Imaging‐Derived Phenotypes as Functional Contributors to 18 Autoimmune Inflammatory Diseases

Advanced Science, EarlyView.
This schematic integrates the eight statistically significant causal relationships identified between 1,366 brain imaging‐derived phenotypes (IDPs) and 18 autoimmune inflammatory diseases (AIDs). Arrows indicate the direction of causality inferred from bidirectional two‐sample MR analyses.
Jinbin Chen, Xin Wang, Haifeng Ding, Bosheng Zheng, Keni Zeng, Chuying Hu, Jiayi Liu, Xiao Zhu, Haibing Yu   +8 more
wiley   +1 more source