Results 51 to 60 of about 5,336,010 (242)

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

HANDMADE EMBROIDERY PATTERN RECOGNITION: A NEW VALIDATED DATABASE

Malaysian Journal of Computing, 2020
Patterns of handmade embroidery are an important part of the culture of a number of African people, particularly in Nigeria. The need to digitally document these patterns emerges in the context of its low patronage despite its quality and richness.
Kudirat Oyewumi Jimoh, Ọdẹ́túnjí Àjàdí Ọdẹ́jọbí, Stephen A. Fọlárànmí , Segun Aina
doaj   +1 more source

Additive technologies and 3d modeling [PDF]

Нанотехнологии в строительстве, 2018
For the last two decades additive technologies (production, further AT and AP respectively) have formed a technological innovation segment of machine building [1, p.
SERGEYEVA Olesya Yurievna
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Cooperative insurance between Islamic jurisprudence and non- Islamic insurance [PDF]

مجلة جامعة الأنبار للعلوم الإسلامية
Cooperative insurance has witnessed widespread adoption, making it necessary to present a study to introduce its principles and forms, and to distinguish it from commercial insurance in order to avoid conceptual confusion.
Dr. khadeega Zwaid khlaif -
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

The effects of rational and emotional sustainability appeals to consumers’ sensory perceptions and emotions

Frontiers in Sustainable Food Systems
Extrinsic cues are widely used by researchers to develop consumers’ perceptions of food. This study aimed to investigate how consumer perceptions and emotional responses to roti prepared by replacing the proportion of wheat flour with wheat bran (an ...
Muhammad Abdullah, Sidra Ghazanfar, Sana Mukhtar, Muhammad Ramzan   +3 more
doaj   +1 more source