Results 171 to 180 of about 65,211 (301)
Advanced Science, EarlyView.(a) The outstanding lubricative properties of natural articular cartilage arise from a composite coating composed of HA, lubricin, and phospholipids at its surface. Notably, lubricin facilitates the enrichment of synovial HA onto cartilage surfaces, and HA complexes with phospholipids, a key component to maintain extremely low friction under high ...
Yongan Lin +12 more
wiley +1 more source
A Nucleolus for Stochastic Cooperative Games
This paper extends the definition of the nucleolus to stochastic cooperative games, that is, to cooperative games with random payoffs to the coalitions.
Suijs, J.P.M.
core
Noninvasive Focal Gene Delivery into the Cerebellum of Non‐Human Primates using Focused Ultrasound
Advanced Science, EarlyView.Focal and non‐invasive viral vector delivery in non‐human primates remains a major challenge in translational neuroscience. Low‐intensity focused ultrasound was used to transiently open the blood–brain barrier and enable targeted gene delivery to the cerebellum.
Noelia Esteban‐García +11 more
wiley +1 more source
Advanced Science, EarlyView.This study reveals the dual role of celecoxib in intervertebral disc degeneration. While low concentrations are protective, high concentrations induce toxicity by upregulating HSP90, which synergizes with USP15 to deubiquitinate and stabilize RBX1. This leads to degradation of COMMD1/ATP7B, copper dyshomeostasis, and ultimately, cuproptosis.
Youfeng Guo +11 more
wiley +1 more source
Advanced Science, EarlyView.MERTK is upregulated in fibrotic macrophages and regulates the expression and activity of SRC and TKS5 through SPP1, mediating transdifferentiation of macrophages‐to‐myofibroblasts (MMT) and promoting pulmonary fibrosis. The figure was created with BioRender.com.
Yungeng Wei +3 more
wiley +1 more source
Advanced Science, EarlyView.This study reveals that Alzheimer's disease–linked APP expression in bone‐forming cells drives skull bone marrow remodeling and alters its vascular connections to the brain. These changes disrupt immune cell trafficking, cerebral blood flow, and cognition. Targeting bone marrow macrophages restores brain function, highlighting a previously unrecognized
Lei Xiong +6 more
wiley +1 more source
Time for play – An exploratory analysis of the changing consumption contexts of digital games
This study posits that Internet technologies are relaxing the coupling constraints required for the consumption of digital games, resulting in entirely different modes of consumption than has been the norm for the past thirty years.
Deal, David
core
Ciclopirox Olamine Inhibits the NLRP3 Inflammasome to Alleviate Inflammatory Diseases
Advanced Science, EarlyView.There is no drug targeting the NLRP3 inflammasome that has been approved for use in clinical settings. Ciclopirox olamine (CPX), an antifungal agent approved by the US Food and Drug Administration (FDA), is identified as a specific and potent NLRP3 inflammasome inhibitor. CPX targets the NACHT domain of NLRP3 at Y381 to impair NLRP3 oligomerization and
Xinyu Xia +7 more
wiley +1 more source
Advanced Science, EarlyView.A continuous conductivity gradient is formed in a porous MXene/melamine foam via directional evaporation, thereby improving impedance matching and enhancing electromagnetic attenuation. The resulting monolithic composite delivers absorption‐dominant EMI shielding with ultralow reflection, offering a simple route toward lightweight EMI shielding ...
Dawei Zhang +6 more
wiley +1 more source
Advanced Science, EarlyView.The aptamer WHY‐3E identifies PrPC as a CRC driver. Stabilized by USP18, endocytosed PrPC forms a LYN/STAT3 complex, upregulating MSN transcription to promote metastasis. Crucially, WHY‐3E sensitively detects PrPC‐positive circulating exosomes, establishing a robust theoretical foundation for non‐invasive clinical diagnostics.
Chunlin Wang +23 more
wiley +1 more source