Results 171 to 180 of about 99,096 (312)

Housing structure shapes dengue transmission dynamics in a rapidly urbanizing Malaysian district. [PDF]

Sci Rep
Dom NC, Hisyam ANS, Saeman MN, Latib NAA, Ramli MI, Fisal ZAM, Yusoff NM, Osman MA, Dapari R, Salleh SA.   +9 more
europepmc   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Integrated housing reconstruction model post-earthquake and tsunamis: Emphasising sustainable construction and local wisdom towards disaster-resilient cities. [PDF]

Jamba
Indramanik IBG, Sudarsana DK, Astana INY, Yana AGA.   +3 more
europepmc   +1 more source

Nias Island traditional houses

, 2008
openaire   +2 more sources

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Social, environmental and policy contexts affecting the feasibility and acceptability of improving household flooring for better health in rural Kenya. [PDF]

PLoS Negl Trop Dis
Fillinger U, Ochwal VA, Legge H, Muli S, Kazungu K, Mcharo C, Mwongeli J, Mwandawiro C, Halliday K, Njomo D, Pullan R, Elson L, Kepha S.   +12 more
europepmc   +1 more source

Agnuside Stabilizes the Complex I Assembly Factor NDUFAF6 to Reinforce Mitochondrial Efficiency and Thermogenic Responsiveness

Advanced Science, EarlyView.
ABSTRACT Brown and beige adipocytes dissipate energy as heat, yet effective strategies to enhance their mitochondrial efficiency remain limited. Here, we identify Agnuside (AGN) as a selective stabilizer of the complex I assembly factor NDUFAF6. AGN directly binds cytosolic NDUFAF6, suppresses its ubiquitination, prolongs its half‐life, and facilitates
Qingwen Zhao, Li Xie, Qianzhuo Wang, Shuying Dai, Bei Li, Yingjuan Zhang, Zhe Sun, Yue Gao   +7 more
wiley   +1 more source

A sustainable house design to improve child health in rural Africa: a cluster-randomized controlled trial. [PDF]

Nat Med
Mshamu S, Mukaka M, Sanga C, Kambanga S, Rutaihwa AD, Bøjstrup TC, Meta J, Mmbando A, Pell C, Adhikari B, Olotu AI, Kapologwe N, White NJ, Dondorp AM, Day NPJ, Imwong M, Deen J, Lindsay SW, Knudsen JB, von Seidlein L.   +19 more
europepmc   +1 more source

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

Gravity-sensing device for measuring bending angles in digestive endoscopes: Design and clinical evaluation. [PDF]

Endosc Int Open
Luo MY, Liu LQ, Lun ZX, Huang CY, Chen XC, Huang Y, Fu ZL, Zhou CK, Yang H, Zhang W.   +9 more
europepmc   +1 more source