Results 211 to 220 of about 3,946,905 (299)

Similarity‐Enhanced Representation Learning of Non‐Canonical Amino Acids for Therapeutic Peptide Modeling

Advanced Science, EarlyView.
Non‐canonical amino acids (ncAAs) enhance peptide therapeutics but remain difficult to model computationally. SinCAA, a similarity‐enhanced pretraining framework, jointly optimizes contrastive learning guided by a novel conformational similarity metric with masked node reconstruction, capturing both functional relationships and chemical identity of ...
Chencheng Xu, Lesong Wei, Jianmin Wang, Yuanpeng Xiong, Ruochi Zhang, Yu Wang, Chao Zha, Qiangcheng Zeng, Xin Gao   +8 more
wiley   +1 more source

Prevalence of malaria and its environmental and socio-cultural determinants in Tandahimba district council, Mtwara Region, Tanzania. [PDF]

Malariaworld J
Ipembe SJ, Mohamed H, Mwakapeje E.
europepmc   +1 more source

Discovery and Optimization of AMT‐676, a CDH17‐Targeting ADC for the Treatment of Advanced Gastrointestinal Cancers

Advanced Science, EarlyView.
AMT‐676 is a novel antibody‐drug conjugate targeting CDH17, an adhesion molecule uniquely exposed on gastrointestinal tumor surfaces. Engineered with an optimized exatecan payload, it demonstrates profound tumor regression and a robust bystander effect across diverse preclinical models.
Ying‐nan Wang, Dan‐yun Ruan, Jing Shi, Yue Huang, Hui Sheng, Ya‐ling Huang, Linjie Ma, Lijun Wang, Caiwei Chen, Yixuan Wang, Yue Zhang, Yi Shen, Qing Zhang, Jianjian Zhang, Yanfang Tang, Jin‐ling Zhang, Jia‐jia Hu, Chen‐yi Wu, Jia‐ying Chen, Xun Meng, Shu‐Hui Liu, Feng Wang   +21 more
wiley   +1 more source

The Effects of the Rearing System, Genotype at the <i>RYR1</i> Locus and Sex of Fattening Pigs on Selected Biochemical Blood Parameters and Concentrations of Cortisol and β-Endorphin. [PDF]

Animals (Basel)
Skrzypczak E, Greguła-Kania M, Kropiwiec-Domańska K, Szulc K, Luciński P, Dąbrowska B, Feddek M, Szwarc Ł, Izbaner Ł, Babicz M, Kliks M.   +10 more
europepmc   +1 more source

Achieving High‐Instantaneous Pulse Power in Contact‐Separation TENG via Series Capacitive Voltage Control Architecture

Advanced Science, EarlyView.
Conventional contact‐separation triboelectric nanogenerators generate high voltage but deliver limited power due to premature charge dissipation. Here, a capacitive charge reservoir architecture decouples charge accumulation from discharge triggering, enabling sequential voltage amplification via floating‐layer capacitive coupling.
Ajay Haridas CP, Prosenjit Das, Kinsuk Naskar, Titash Mondal   +3 more
wiley   +1 more source

Advancing circumpolar maternal and child health: insights from the ICARP IV session. [PDF]

Int J Circumpolar Health
Ingemann C, Ibrahimi J, Allen MD, Beans JA, Brown K, Caughey A, Johnston P, Moffit P, Nordsletta ÁS, Paulsen S, Peterson M, Plamondon T, Chatwood S.   +12 more
europepmc   +1 more source

Mitochondria‐Targeted Multimodal Nanotherapeutics Suppress Oxidized mtDNA‐Driven Inflammation at the Source

Advanced Science, EarlyView.
Ox‐mtDNA fragments escaping from mitochondria drive robust inflammatory responses. A targeted nanoplatform simultaneously inhibits mitochondrial FEN1‐mediated mtDNA cleavage and scavenges ROS, preventing the generation of immunogenic Ox‐mtDNA fragments. The released SeNPs further promote autophagic clearance of cytosolic mtDNA. Consequently, cGAS‐STING,
Wen‐Ling Li, Juan Cao, Yu‐Lin Wang, Yu‐Han Fan, Jia‐Qi Xu, Xian Wu Cheng, Lei Xing, Hu‐Lin Jiang   +7 more
wiley   +1 more source

Thermal comfort in relation to housing and tuberculosis status among individuals aged ≥15 years in Padang, West Sumatra Province, Indonesia. [PDF]

Front Public Health
Prima RR, Geater AF, Chongsuvivatwong V, Taweekun J, Djafri D.   +4 more
europepmc   +1 more source

A Multifunctional Mesoporous Janus Separator With Optimized Mass Transport Regulation Enabling 800‐Cycle Lithium‐Oxygen Batteries

Advanced Science, EarlyView.
To resolve the fundamental cycling decay of lithium‐oxygen batteries arising from lithium dendrite propagation, anode corrosion, and cathode passivation, we fabricate a mesoporous silica/polyurethane Janus separator integrating interfacial protection and mass transport modulation, which markedly enhances battery cycling stability and cycle life ...
Hailiang Mu, Anlong Liu, Kun Luo, Yaming Pang, Chengde Xie, Xiaoteng Liu, Zhihong Luo, Guangbin Zhu, Yucheng Wang, Qirong Liu, Yongbing Tang   +10 more
wiley   +1 more source