Results 51 to 60 of about 1,105,976 (310)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Prevalence of herbal medicine use for maternal conditions in Tanzania: a systematic review and meta-analysis

open access: yesFrontiers in Pharmacology
BackgroundStudies reported the prevalence of herbal medicines used for various maternal conditions across regions in Tanzanian communities. However, the lack of a national estimate of herbal medicine use makes it challenging for policymakers, herbal ...
Hamisi S. Japhari   +4 more
doaj   +1 more source

Statistical analysis in support of maintaining a healthy traditional Siamese cat population

open access: yesGenetics Selection Evolution, 2021
Background For many years, breeders of companion animals have applied inbreeding or line breeding to transfer desirable genetic traits from parents to their offspring.
Arthur M. A. Pistorius, Ineke Blokker
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

A survey of social-psychological variables used in studies of family planning [PDF]

open access: yes, 1971
For more about the East-West Center, see http://www.eastwestcenter.org/Social-psychological variables such as perception (of the population problem, of family planning and others' opinions) and motivation are critical factors in the diffusion of family ...
Rosario, Florangel Z. (Florangel Zuleta)   +1 more
core  

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Use of traditional medicine in middle-income countries: a WHO-SAGE study [PDF]

open access: yes, 2016
It is frequently stated in the scientific literature, official reports and the press that 80% of Asian and African populations use traditional medicine (TM) to meet their healthcare needs; however, this statistic was first reported in 1983.
Chilton, Peter J.   +7 more
core   +1 more source

Transition in metabolic health phenotypes across general adiposity categories and association with the risk of depression: a prospective analysis

open access: yesEuropean Psychiatry
Background The association between obesity and depression may partly depend on the contextual metabolic health. The effect of change in metabolic health status over time on subsequent depression risk remains unclear.
Yunyi Zhu   +7 more
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Methods of demographic estimation for statistically underdeveloped areas [PDF]

open access: yes, 1971
For more about the East-West Center, see http://www.eastwestcenter.org/The two main new approaches to generate data--surveys and sample registration--do not exhaust the full range of possible sources of information on demographic processes that may be ...
Demeny, Paul George   +1 more
core  

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