Results 81 to 90 of about 3,380,457 (302)

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Circulating BCKAs are closely associated with adipose tissue insulin resistance in type 2 diabetes

Diabetology & Metabolic Syndrome
Background This study aimed to examine the association between branched-chain amino acids/branched-chain α-keto acids (BCAAs/BCKAs) and adipose tissue insulin resistance (Adipo-IR) in patients with type 2 diabetes mellitus (T2DM).
Jie Gao, Mai Re YanMu Rouzi, Haofan Yang, Wenhao Zheng, Liang Wang, Tao Lei, Jun Lu   +6 more
doaj   +1 more source

Using Artificial Intelligence for Model Selection

, 2003
We apply the optimization algorithm Adaptive Simulated Annealing (ASA) to the problem of analyzing data on a large population and selecting the best model to predict that an individual with various traits will have a particular disease.
Goldstein, Darin, Murray, William, Yang, Binh   +2 more
core   +2 more sources

“The thing is, to adapt is traditional”: Environmental Change and its Effects on Traditional Ecological Knowledge in the Eastern United States [PDF]

, 2015
In this essay, I examine the transformation of traditional ecological knowledge, particularly that concerning plant knowledge pertaining to medicine. I argue that this transformation is a result of an environmental history influenced by the presence of a
Bassett, Alecia
core   +1 more source

Evolutionary dynamics of the chloroplast genome in Daphne (Thymelaeaceae): comparative analysis with related genera and insights into phylogenetics

FEBS Open Bio, EarlyView.
Comparative analysis of chloroplast genomes from 14 genera of Thymelaeaceae revealed variation in gene content, ranging from 128 to 142 genes, primarily influenced by IR expansion/contraction events and pseudogenization of ndhF, ndhI, and ndhG. Two large inversions were detected within the large single‐copy region, including a synapomorphic inversion ...
Abdullah, Hui Li, Rushan Yan, Chengyu Chen, Madiha Islam, Abdul Majid, Ibrar Ahmed, Parviz Heidari, Xiaoxuan Tian   +8 more
wiley   +1 more source

The evolution of farm size distribution: revisiting the Markov chain model [PDF]

In this paper, a continuous version of the Markov Chain Model (MCM) is proposed to project the number and the population structure of farms. It is then applied to the population of professional French farms.
Piet, Laurent
core   +1 more source

Impact of a senior research thesis on students' perceptions of scientific inquiry in distinct student populations

FEBS Open Bio, EarlyView.
This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart, Haley L. Zubyk, Michelle Ogrodnik, Caitlin E. Mullarkey, Felicia Vulcu   +4 more
wiley   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

AGRICULTURAL ADAPTATION TO URBANIZATION IN SOUTHEASTERN PENNSYLVANIA [PDF]

Most agricultural output in the northeastern United States comes from counties that have experienced significant development. A mail survey, with 300 responses, was conducted in southeastern Pennsylvania to determine farmer adaptation to urbanization in ...
Findeis, Jill L., Larson, Janelle M., Smith, Stephen M.   +2 more
core   +1 more source

TMC4 localizes to multiple taste cell types in the mouse taste papillae

FEBS Open Bio, EarlyView.
Transmembrane channel‐like 4 (TMC4), a voltage‐dependent chloride channel, plays a critical role in amiloride‐insensitive salty taste transduction. TMC4 is broadly expressed in all mature taste cell types, suggesting a possible involvement of multiple cell types in this pathway.
Momo Murata, Yoshikazu Saito, Yoichi Kasahara, Wataru Fujii, Takumi Misaka, Tomiko Asakura, Masataka Narukawa   +6 more
wiley   +1 more source