Results 91 to 100 of about 499,190 (304)
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
The roots of demotivation in studying English: Sociocultural values among students in a rural area
Studies in English Language and EducationThis confessional ethnographic study strives to reveal the sociocultural values that are suspected as trigger factors of students’ demotivation in studying English.
La Dunifa
doaj +1 more source
The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer
Molecular Oncology, EarlyView.Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad +2 more
wiley +1 more source
Something old, something new: Bricolage and wedding traditions [PDF]
, 2016 While the wedding spectacle grows in British culture, there is a simultaneous erosion of marriage rates, which have once again started to decline.
Carter, J.
core
Mu Kara SaniCet article vise à évaluer l’efficacité des mécanismes de justice traditionnelle au Niger dans leur capacité à résoudre les conflits au XIXe siècle. Cette étude permet de comprendre non seulement l’histoire du pays, mais aussi les interactions entre ...
Hassimou ALAKARBO
doaj
“Emplaced” Tradition. The Continuity of Folk Tradition in the Landscape
Traditiones, 2012 Since the expulsion of “folk” from the academic discourse the research of folk traditions seems inappropriate for a modern ethnologist. However, the landscapes are endowed with collective memory and meaning, given by the tradition. In the “emplaced” tradition can be discerned some continuity by which continuity includes change. Moreover, the aim of the
openaire +3 more sources
Molecular Oncology, EarlyView.Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler +3 more
wiley +1 more source
, 2015 Hazel Ouano Alpuerto is a Filipino-Canadian living in St. John's. She is a psychiatric registered nurse by profession, and works with Eastern Health with Mental Health and Addictions.
Jarvis, Dale
core
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source