Results 121 to 130 of about 3,212,345 (310)

In‐Depth Profiling Highlights the Effect of Efgartigimod on Peripheral Innate and Adaptive Immune Cells in Myasthenia Gravis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Myasthenia gravis (MG) is an autoimmune disorder characterized by antibody‐mediated complement activation. Efgartigimod, a neonatal Fc receptor (FcRn) antagonist, is approved for treating generalized MG (gMG). However, its modulatory effects on upstream innate and adaptive immune cells remain largely unexplored.
Lei Jin, Liu Dong, Ying Wang, Dingxian He, Chong Yan, Jianying Xi, Haoqin Jiang, Yu Shi, Ming Guan, Chongbo Zhao, Jie Song, Sushan Luo   +11 more
wiley   +1 more source

Estimating the Railway Network Capacity Utilization with Mixed Train Routes and Stopping Patterns: A Multiobjective Optimization Approach

Journal of Advanced Transportation
Railway capacity estimation problem is typically defined as estimating the maximum number of trains that can be operated in a railway section within a given time interval.
Zhengwen Liao, Haiying Li, Jianrui Miao, Lingyun Meng   +3 more
doaj   +1 more source

Graph Neural Network for Traffic Forecasting: A Survey [PDF]

Expert systems with applications, 2021
Weiwei Jiang, Jiayun Luo
semanticscholar   +1 more source

Diagnostic Utility of the ATG9A Ratio in AP‐4–Associated Hereditary Spastic Paraplegia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Adaptor protein complex 4–associated hereditary spastic paraplegia (AP‐4‐HSP), a childhood‐onset neurogenetic disorder and frequent mimic of cerebral palsy, is caused by biallelic variants in the adaptor protein complex 4 (AP‐4) subunit genes (AP4B1 [for SPG47], AP4M1 [for SPG50], AP4E1 [for SPG51], and AP4S1 [for SPG52]).
Habibah A. P. Agianda, Hyo‐Min Kim, Nicole Battaglia, Joshua Rong, Amy Tam, Enrique Gonzalez Saez‐Diez, Cornelius F. Boerkoel, Afshin Saffari, Vicente Quiroz, Luca Schierbaum, Zainab Zaman, Katerina Bernardi, Darius Ebrahimi‐Fakhari   +12 more
wiley   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Smart, Bio‐Inspired Polymers and Bio‐Based Molecules Modified by Zwitterionic Motifs to Design Next‐Generation Materials for Medical Applications

Advanced Functional Materials, EarlyView.
Bio‐based and (semi‐)synthetic zwitterion‐modified novel materials and fully synthetic next‐generation alternatives show the importance of material design for different biomedical applications. The zwitterionic character affects the physiochemical behavior of the material and deepens the understanding of chemical interaction mechanisms within the ...
Theresa M. Lutz, Jonas De Breuck, Sahar Salehi, Meike N. Leiske   +3 more
wiley   +1 more source

Coordinated Scheduling of Automated Loading Platforms in Commercial Logistics

Journal of Advanced Transportation
Automated warehousing and distribution has been an innovation approach to reduce costs and increase efficiency in logistics industry. Taking the intelligent demonstration warehouse in a commercial logistics park in Shandong, China as the background, this
Xiaoqian Nie, Lu Qin, Zixuan Peng, Chuanhan Zhou   +3 more
doaj   +1 more source

Fluorescent Nanodiamonds Based Theranostic Platform for pH‐Sensitive Drug Delivery and Quantum Sensing

Advanced Functional Materials, EarlyView.
A multifunctional nanodiamond platform enables pH‐triggered Diazoxide (DZX) delivery and quantum sensing of subcellular radical dynamics in triple‐negative breast cancer cells. Diamond relaxometry revealed reduced lysosomal radicals during DZX‐induced mitochondrial radical elevation, providing insights into redox modulation and organelle‐ resolved ...
Kaiqui Wu, Siyu Fan, Yue Zhang, Willem Woudstra, Thomas Mulder, Laurens Boscher Navarro, Jur van Dijken, Katja Loos, Romana Schirhagl   +8 more
wiley   +1 more source

A Multiaircraft Path Distributive Planning Method via Autonomous Self-Separation Operation Mode

Journal of Advanced Transportation
In this paper, a multiaircraft path planning method framework for autonomous operation and distributed decision-making was proposed. The core content of this framework consists of two parts: single-aircraft path planning and multiaircraft path ...
Ruiying Wen, Jiaxing He, Yupeng Guo, Hongyong Wang   +3 more
doaj   +1 more source

Traffic Speed Report No. 124 : Traffic Report

, 1991
This report is an analysis of spot speed observations made during the 1990 summer months of May, June, July and August. All observations were made of free-flowing vehicles on level, tangent sections of rural and urban highways under favorable conditions. All observations were made during daylight hours.
Cochran, David L., Genda, Donald W.
openaire   +4 more sources