Results 251 to 260 of about 7,816,845 (321)

Cuproptosis and Disulfidptosis Converge to Empower PD‐L1 Checkpoint Therapy via Cadict‐Induced PD‐L1 Translation

Advanced Science, EarlyView.
This study introduces Cadict, an EGFR‐targeted nanodrug that co‐delivers cuproptosis and disulfidptosis inducers to overcome immune resistance. Cadict synergistically enhances tumor cytotoxicity and sensitizes cancers to ICIs by upregulating PD‐L1 via an Eif5b‐dependent translation mechanism, fostering a potent antitumor immune response and ...
Shaoqing Huang, Shiyao Song, Xinhua Zhang, Jialing Gao, Ruihan Pu, Jiatong Dai, Xiaoxue Wu, Lulu Chen, Qinghai Li, Xiaoting Liu, Qi Zhou, Mei Song, Weiling He   +12 more
wiley   +1 more source

Maternal and Newborn Factors Associated with Meconium Metal Concentrations: A Cross-Sectional Study. [PDF]

Toxics
Mimica B, Pribisalic A, Knezovic Z, Knezovic N, Sutlovic D.   +4 more
europepmc   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Gaseous emissions from brake wear can form secondary particulate matter. [PDF]

Sci Rep
Patel A, Aggarwal S, Bard L, Durif O, Introna M, Juárez-Facio AT, Tu M, Elihn K, Nozière B, Olofsson U, Steimer SS.   +10 more
europepmc   +1 more source

OCIAD2 Stabilizes Integrin β1 Signaling Through SNX17‐Mediated Endosomal Recycling to Lipid Rafts and Modulates Cisplatin Response in HNSCC

Advanced Science, EarlyView.
This study identifies OCIAD2 as a critical regulator of cisplatin resistance in HNSCC. Mechanistically, OCIAD2 stabilizes integrin β1 through a direct physical interaction and facilitates its SNX17‐dependent endosomal recycling to lipid raft microdomains. Targeting OCIAD2 disrupts integrin β1 trafficking and significantly enhances cisplatin sensitivity,
Li Cui, Shanshan Si, Min Ye, Pei Lin, Meiyan Zou, Yunfan Lin, Xu Chen, Bing Guo, Wenjuan Sun, Xinyuan Zhao   +9 more
wiley   +1 more source

Spatial evolution of international air cargo network connectivity in China: 1996-2019. [PDF]

Sci Rep
Xu X, Liu J, Jiang J, Lin B, Li L.
europepmc   +1 more source

Cross-Layer Analysis of Machine Learning Models for Secure and Energy-Efficient IoT Networks. [PDF]

Sensors (Basel)
Mustafa R, Sarkar NI, Mohaghegh M, Pervez S, Vohra O.   +4 more
europepmc   +1 more source

Chemical investigation of polycyclic aromatic hydrocarbon sources in an urban area with complex air quality challenges. [PDF]

Sci Rep
Szramowiat-Sala K, Marczak-Grzesik M, Karczewski M, Kistler M, Giebl AK, Styszko K.   +5 more
europepmc   +1 more source

Effective tree species for local air quality management

, 2000
Beckett, K.P., Freer Smith, P.H., Taylor, Gail   +2 more
core  

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Tranalyzer: Versatile high performance network traffic analyser

2016 IEEE Symposium Series on Computational Intelligence (SSCI), 2016
IP-based networks are prone to hardware failures, software errors and misconfigurations. This leads to service outages, such as those experienced by American Airlines in 2015. Moreover, cyber threats are becoming ever more sophisticated. As demonstrated by recent success stories of malware, such as the crimeware BlackEnergy, current defence solutions ...
Stefan Burschka, Benoit Dupasquier
openaire   +2 more sources