Results 31 to 40 of about 1,316,228 (290)

A zone-based traffic assignment algorithm for scalable congestion reduction

ICT Express, 2017
Traffic assignment networks are networks with pseudo-static behavior: the network topology is constant but the cost of each edge changes in real-time. Extensive work has been completed in the literature to develop efficient traffic assignment algorithms ...
Taylor Cox, Parimala Thulasiraman
doaj   +1 more source

Application of Traffic Weighted Multi-Map Optimization Strategies to Traffic Assignment

IEEE Access, 2021
Traffic Assignment Problem (TAP) is a critical issue for transportation and mobility models that deals mainly with the calculus and delivery of best-cost routes for the trips in a traffic network.
Alvaro Paricio, Miguel A. Lopez-Carmona
doaj   +1 more source

A Temporal Domain Decomposition Algorithmic Scheme for Large-Scale Dynamic Traffic Assignment

International Journal of Transportation Science and Technology, 2012
With emergent interest of Simulation-Based Dynamic Traffic Assignment (SBDTA) in the field of transportation network modeling, deployment of SBDTA models for traffic operations and transportation planning have increased significantly in recent years.
Eric J. Nava
doaj   +1 more source

Formulation and solution for calibrating boundedly rational activity-travel assignment: An exploratory study

Communications in Transportation Research, 2023
Parameter calibration of the traffic assignment models is vital to travel demand analysis and management. As an extension of the conventional traffic assignment, boundedly rational activity-travel assignment (BR-ATA) combines activity-based modeling and ...
Dong Wang, Feixiong Liao
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Data‐driven discovery of gene expression markers distinguishing pediatric acute lymphoblastic leukemia subtypes

Molecular Oncology, EarlyView.
This study investigates gene expression differences between two major pediatric acute lymphoblastic leukemia (ALL) subtypes, B‐cell precursor ALL, and T‐cell ALL, using a data‐driven approach consisting of biostatistics and machine learning methods. Following analysis of a discovery dataset, we find a set of 14 expression markers differentiating the ...
Mona Nourbakhsh, Nikola Tom, Anna Schrøder Lassen, Helene Brasch Lind Petersen, Ulrik Kristoffer Stoltze, Karin Wadt, Kjeld Schmiegelow, Matteo Tiberti, Elena Papaleo   +8 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study

Advanced Biology, EarlyView.
Although aging is the most important risk factor for several neurodegenerative diseases, the molecular effects of physiological aging are still understudied. By applying spatially‐resolved proteomic analyses of the human substantia nigra pars compacta, alterations in vesicular trafficking and mitochondrial proteins are observed, as well as reduced ...
Britta Eggers, Maximilian Hausherr, Michel Lim, Karin Schork, Bilhan Karacora, Robin Grugel, Martin Eisenacher, Isabel Gil Aldea, Peter Riederer, Manfred Gerlach, Katrin Marcus   +10 more
wiley   +1 more source

Incorporating Traffic Models into Seismic Damage Analysis of Bridge Road Networks: A Case Study in Central Italy

Infrastructures, 2023
Transportation networks are one of the most vulnerable civil infrastructures during an earthquake and an estimation of traffic impacts in the post-earthquake scenario is a crucial aspect in the context of risk assessment and evaluation of remedial ...
Alessandro Rasulo, Sofia Nardoianni, Azzurra Evangelisti, Mauro D’Apuzzo   +3 more
doaj   +1 more source

Endocytic Programming via Porous Silicon Nanoparticles Enhances TLR4 Nanoagonist Potency for Macrophage‐Mediated Immunotherapy

Advanced Functional Materials, EarlyView.
Porous silicon nanoparticles (PSiNPs) reprogram macrophage endocytosis of manganese@albumin‐based TLR4 nanoagonists, driving TRIF‐biased TLR4 signaling, eliciting robust proinflammatory responses, and potentiating macrophage‐mediated immunotherapeutic effects against NSCLC.
Xiaomei Zhang, Huiying Li, Shuodan Huang, Linxuan Zhang, Yan Gao, Ruoran Wang, Xiaoyu Wang, Hélder A. Santos, Zhenyu Yin, Bing Xia   +9 more
wiley   +1 more source