Results 41 to 50 of about 4,103,347 (253)

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

open access: yesFEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise   +5 more
wiley   +1 more source

Traffic Demand Forecasting for Port Services [PDF]

open access: yes, 2011
Successful management of any sea port depends primarily on the harmonisation of transport supply and demand, whereas their incompatibility leads to a number of problems. The port, i.e.
Poletan Jugović, Tanja   +5 more
core   +1 more source

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

open access: yesFEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux   +7 more
wiley   +1 more source

Research on short-term traffic flow prediction based on the PCC-IGA-LSTM model

open access: yesAutomatika
Real-time and accurate short-term traffic flow forecasting can provide important decision support for traffic guidance and management. To effectively address the spatial–temporal feature mining problem in short-term traffic flow prediction for complex ...
Junxi Zhang   +3 more
doaj   +1 more source

A Sample-Rebalanced Outlier-Rejected $k$ -Nearest Neighbor Regression Model for Short-Term Traffic Flow Forecasting

open access: yesIEEE Access, 2020
Short-term traffic flow forecasting is a fundamental and challenging task due to the stochastic dynamics of the traffic flow, which is often imbalanced and noisy.
Lingru Cai   +5 more
doaj   +1 more source

Spatiotemporal traffic-flow dependency and short-term traffic forecasting

open access: yes, 2008
Short-term traffic forecasting is playing an increasing role in modern transport management. Although many short-term traffic forecasting methods have been explored, the spatiotemporal dependency of traffic flow, an important characteristic of traffic ...
Yue, Y, Yeh, AGO
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

open access: yesFEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward   +2 more
wiley   +1 more source

Membrane composition and thermodynamic identity as boundaries of life for synthetic cell research

open access: yesFEBS Letters, EarlyView.
What makes a cell a cell? The boundary of a living cell is not just a wall. Read as a Markov blanket, the membrane separates internal from external states, generating identity and non‐equilibrium order. Can this identity be rebuilt from scratch in a synthetic cell?
Caterina Presutti, Bert Poolman
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

open access: yesFEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana   +5 more
wiley   +1 more source

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