Results 31 to 40 of about 5,189,325 (247)

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

A Two-Stage Decomposition-Reinforcement Learning Optimal Combined Short-Time Traffic Flow Prediction Model Considering Multiple Factors

Applied Sciences, 2022
Accurate short-term traffic flow prediction is a prerequisite for achieving an intelligent transportation system to proactively alleviate traffic congestion.
Dayi Qu, Kun Chen, Shaojie Wang, Qikun Wang   +3 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

A deep network with analogous self‐attention for short‐term traffic flow prediction

IET Intelligent Transport Systems, 2021
Short‐term traffic flow prediction plays a crucial role in research and application of intelligent transportation system. Neural network algorithm can use the big data for training and has more advantages over other prediction models in traffic features ...
Zhao Zhang, Xiaohong Jiao
doaj   +1 more source

Traffic Flow Forecast based on Vehicle Count [PDF]

, 2023
Real-time traffic predictions have now become a time-being need for efficient traffic management due to the exponentially increasing traffic congestion In this paper a more pragmatic traffic management system is introduced to address traffic congestion
Pavanee Weebadu Liyanage, K.P.G.C.D. Sucharitharathna   +1 more
core  

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Traffic flow prediction of urban road network based on LSTM-RF model

Journal of Measurement Science and Instrumentation, 2020
Traffic flow prediction, as the basis of signal coordination and travel time prediction, has become a research point in the field of transportation. For traffic flow prediction, researchers have proposed a variety of methods, but most of these methods ...
ZHAO Shu-xu, ZHANG Bao-hua
doaj  

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

A comprehensive review of traffic flow prediction: from traditional models to deep learning architectures

Digital Transportation and Safety
Traffic congestion gradually becomes an increasingly serious problem in cities. Intelligent transportation systems (ITS) have been introduced to alleviate traffic congestion.
Heng Zhang, Zhizhe Lin, Jinglin Zhou, Jiaxin Sun, Teng Zhou, Chunjie Cao   +5 more
doaj   +1 more source