Results 191 to 200 of about 76,767 (261)

Epidemiological characteristics and hospital and inpatient burdens of trauma patients in Xuzhou from 2019 to 2023. [PDF]

Ann Med
Wu J, Wang L, Zhou G, Xu Z, Li S, Feng S, Liu X.   +6 more
europepmc   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

BigFlow-NIDS: A large-scale dataset for network intrusion detection in big data environment. [PDF]

Data Brief
Uddin MB, Arefin MS, Hussain MMM.
europepmc   +1 more source

OCIAD2 Stabilizes Integrin β1 Signaling Through SNX17‐Mediated Endosomal Recycling to Lipid Rafts and Modulates Cisplatin Response in HNSCC

Advanced Science, EarlyView.
This study identifies OCIAD2 as a critical regulator of cisplatin resistance in HNSCC. Mechanistically, OCIAD2 stabilizes integrin β1 through a direct physical interaction and facilitates its SNX17‐dependent endosomal recycling to lipid raft microdomains. Targeting OCIAD2 disrupts integrin β1 trafficking and significantly enhances cisplatin sensitivity,
Li Cui, Shanshan Si, Min Ye, Pei Lin, Meiyan Zou, Yunfan Lin, Xu Chen, Bing Guo, Wenjuan Sun, Xinyuan Zhao   +9 more
wiley   +1 more source

Identification and detection of DDoS attack on smart home infrastructure using machine learning models. [PDF]

Sci Rep
Raja TV, Ezziane Z, He J, Ma X, Wali-Zubair Kazaure A.   +4 more
europepmc   +1 more source

Deciphering and Targeting the Schwannoma‐Neuron‐Macrophage Crosstalk for the Treatment of Schwannomatosis and Associated Pain

Advanced Science, EarlyView.
We established patient‐derived SWN cell lines and orthotopic PDX models that recapitulate patient pain phenotypes, alongside a novel intravital DRG imaging platform to track macrophage infiltration and neuronal pain responses. Using these models, we define HMGB1–CCL2–IL‐6 signaling crosstalk driving pain and identify EGF signaling as a key regulator of
Zhenzhen Yin, Limeng Wu, Yanling Zhang, Yao Sun, Grace Y. Lee, Simeng Lu, Xing Gao, John W. Chen, Sonu Subudhi, William Ho, Chao Zhu, Jun Ren, Gino B. Ferraro, Alona Muzikansky, Anat Stemmer‐Rachamimov, Jianren Mao, Scott R. Plotkin, Lei Xu   +17 more
wiley   +1 more source

Comprehensive and spatially detailed passenger vehicle and truck traffic volume data for the United States estimated by machine learning. [PDF]

Data Brief
Antonczak B, Fay M, Chawla A, Rowangould G.   +3 more
europepmc   +1 more source

An Insulin‐Exosome‐TNFAIP8 Axis Drives Stromal Fibrosis and Therapeutic Resistance in Pancreatic Cancer

Advanced Science, EarlyView.
In pancreatic ductal adenocarcinoma (PDAC), insulin is associated with activation of PI3K/AKT–RAB3A signaling and enhanced secretion of TNFAIP8‐enriched exosomes from tumor cells. Uptake of these exosomes by fibroblasts is linked to TRIM21‐dependent STAT1 degradation and the emergence of myofibroblastic CAF–associated features, accompanied by increased
Zhenyu Li, Li Chen, Tao Wang, Haiyang Jiang, Huijuan Wang, Mengyu Li, Guanpeng Xie, Chunhua Xi, Han Yan, Chunhui Lu, Chenchen Li, Hanyu Zhu, Feihu Sun, Lingdi Yin, Jun Yu, Yi Miao   +15 more
wiley   +1 more source

An efficient federated learning based defense mechanism for software defined network cyber threats through machine learning models. [PDF]

Sci Rep
Amin R, Costanzo A, Alzabin LR, Aqdus A, Kamarulzaman SF, Alshehri AH.   +5 more
europepmc   +1 more source

Ship wake-induced water column mixing and meter-scale seabed erosion in the Baltic Sea. [PDF]

Nat Commun
Geersen J, Feldens P, Rollwage L, Baumann LM, Krämer K, Westfeld P, Krastel S, Ahmerkamp S, Tauber F, von Deimling JS.   +9 more
europepmc   +1 more source