Results 211 to 220 of about 422,634 (302)

Advances in GPCRs Associated With Wnt Signaling Within the Auditory System

open access: yesMedicine Bulletin, EarlyView.
ABSTRACT G protein‐coupled receptors (GPCRs) that interact with the Wnt signaling pathway are pivotal for auditory system homeostasis, as they orchestrate inner ear development, hair cell (HC) regeneration, and hearing preservation. Frizzled (FZD) receptors, the core Wnt‐related GPCRs, bind Wnt ligands and co‐receptors (e.g., LRP5/6) to activate both ...
Liang Wang   +3 more
wiley   +1 more source

Long‐Term Exposure to Air Pollution and Incidence of Parkinson's Disease: A Danish Nationwide Administrative Cohort Study

open access: yesMovement Disorders, EarlyView.
Abstract Background Long‐term exposure to air pollution has been linked to Parkinson's disease (PD) incidence, yet evidence is mixed, partly because of challenges with PD diagnosis and definition. We examined this association in a nationwide administrative cohort.
Thomas Cole‐Hunter   +14 more
wiley   +1 more source

Smart Integration of Structural Biology and Medicinal Chemistry to Unlock Target‐Driven Drug Discovery

open access: yesMedicinal Research Reviews, EarlyView.
ABSTRACT To enhance drug discovery efforts, medicinal chemists should evaluate, filter, and utilize relevant structural information about target proteins. Acquiring and interpreting protein structures is crucial for elucidating ligand‐receptor interactions and addressing ADME‐related considerations, making it an essential aspect of medicinal chemistry.
Matteo Rossi Sebastiano   +4 more
wiley   +1 more source

Interaction Between Vortex‐Induced Vibrations and Base Vibrations in Piezoelectric Harvesters

open access: yesInternational Journal of Mechanical System Dynamics, EarlyView.
ABSTRACT In the present era, powering sensors using green energy is a significant challenge. One promising solution for the power supply of small sensors relies on piezoelectric energy harvesters excited by vortex‐induced vibrations (VIVs) generated by wind.
Michele Tonan   +3 more
wiley   +1 more source

Road-traffic noise exposure and coronary atherosclerosis in the Swedish CArdioPulmonary bioImage Study (SCAPIS). [PDF]

open access: yesEnviron Epidemiol
Murzabekov M   +18 more
europepmc   +1 more source

Nonlinear Vibration Characteristic Analysis of Electric Vehicle–Road Coupling System

open access: yesInternational Journal of Mechanical System Dynamics, EarlyView.
ABSTRACT In‐wheel motor drive is the developing direction of automobile electrification and intelligence. However, the increased unsprung mass in in‐wheel motor‐driven electric vehicles (IWMEVs) leads to higher dynamic tire loads, thereby intensifying vehicle–road coupling interactions. To address this problem, an 11‐degree‐of‐freedom nonlinear dynamic
Guizhen Feng, Shaohua Li, Xuewei Wang
wiley   +1 more source

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