Results 121 to 130 of about 359,562 (287)

HRS Degradation‐Induced Nicotinamide Deficiency in Placental Extracellular Vesicles Triggers Preeclampsia by Disrupting Maternal‐Fetal Immune Homeostasis

Advanced Science, EarlyView.
This study shows that lower NAM levels in PE‐derived pEVs correlate with disease severity. NAM‐deficient pEVs reduce Th1 and Th17 inhibition, leading to PE‐like symptoms. NAM in pEVs inhibits Th1 via SIRT1 and Th17 via macrophages. Reduced NAM in PE‐EVs is due to decreased HRS expression in trophoblasts, resulting from elevated HSP27.
Haiyi Fei, Yuhan Lin, Xiu Liu, Xiaohong Zhu, Xiaowen Lu, Zhan Shi, Fan Jia, Shiqian Xu, Ling Fang, Lingling Jiang, Songying Zhang   +10 more
wiley   +1 more source

Cellular Traffic Prediction Using Online Prediction Algorithms

The advent of 5G technology promises a paradigm shift in the realm of telecommunications, offering unprecedented speeds and connectivity. However, the efficient management of traffic in 5G networks remains a critical challenge. It is due to the dynamic and heterogeneous nature of network traffic, varying user behaviors, extended network size, and ...
Mehri, Hossein, Chen, Hao, Mehrpouyan, Hani   +2 more
openaire   +2 more sources

A Mussel‐Inspired Bioadhesive Patch to Selectively Kill Glioblastoma Cells

Advanced Science, EarlyView.
An innovative mussel‐inspired bioadhesive patch has been developed for post‐surgical glioblastoma treatment. The patch, which adheres strongly in biological environments, releases a localized treatment. This treatment, acting via reactive oxygen species, shows specific toxicity to glioblastoma cells.
Jose Bolaños‐Cardet, Sara Pugliese, Jordi Bruna, Daniel Ruiz‐Molina, Salvio Suárez‐García, Victor J. Yuste   +5 more
wiley   +1 more source

Type I Interferon Pathway Activation Disrupts Monocyte Maturation and Enhances Immune Evasion in Multiple Myeloma

Advanced Science, EarlyView.
This study shows that monocytes in multiple myeloma display an excessive interferon response, leading to transcriptional reprogramming and altered differentiation. Using single‐cell sequencing, coculture experiments, and patient samples before and after therapy, the authors demonstrate that induction treatment reduces this interferon response ...
Jian Cui, Jingwei Wang, Xiaoyun Li, Lina Wang, Xuehan Mao, Rui Lyv, Wenqiang Yan, Jingyu Xu, Jieqiong Zhou, Chenxing Du, Shuhui Deng, Mu Hao, Yan Xu, Shuhua Yi, Dehui Zou, Tao Cheng, Xin Gao, Lugui Qiu, Gang An   +18 more
wiley   +1 more source

Modelling the Traffic Prediction at the Direct Level of TMS Systems

Logi
The paper deals with the issue of modelling traffic prediction in operational applications of infrastructure managers to increase the quality of decision-making at the direct level of railway traffic management.
Kučera Petr, Šturma Martin, Bachratý Hynek, Drdla Pavel   +3 more
doaj   +1 more source

Short-term traffic flow prediction at isolated intersections based on parallel multi-task learning

Systems Science & Control Engineering
This paper proposes a novel phase-based short-term traffic flow prediction method based on parallel multi-task learning for isolated intersections. Different from traditional short-term traffic flow prediction methods, we take the traffic flow of each ...
Bao-Lin Ye, Shiwei Zhu, Lingxi Li, Weimin Wu   +3 more
doaj   +1 more source

State Transition Graph-Based Spatial-Temporal Attention Network for Cell-Level Mobile Traffic Prediction. [PDF]

Sensors (Basel), 2023
Shi J, Cui L, Gu B, Lyu B, Gong S.
europepmc   +1 more source

Gαi1/3 Is a Novel Regulatory Target for RANKL Signal Transduction and Osteoporosis

Advanced Science, EarlyView.
ABSTRACT Osteoporosis, characterized by progressive bone loss and increased fracture risk, is a growing concern as the population ages. Current treatments, though advanced, remain limited, underscoring the necessity for novel therapeutic targets. Recent studies have shown that the immune system plays a key role in osteoporosis, with osteoclasts driving
Chaowen Bai, Mingchao Zhang, Le Liu, Lide Tao, Chenyang Xu, Hao Chai, Xin Shi, Yin Wang, Xiaopei Zhang, Qiong Chen, Dong Liu, Jinyu Bai, Chang She, Xiaozhong Zhou, Cong Cao, Huajian Shan   +15 more
wiley   +1 more source

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

Advanced Science, EarlyView.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong, Fang Liu, Dawei Wang, Yanfen Li, Man Zhang, Yuting Zhou, Gengshen Song   +6 more
wiley   +1 more source

Spatial heterogeneity of heavy metals in contaminated soil using hyperspectral inversion models: a case study of Dongting lake region, south-central China

Scientific Reports
Heavy metal pollution in soil seriously threatens ecosystem and human health. However, traditional monitoring methods usually rely on intensive sampling, which is costly and difficult to be extended to large regional scales. Based on Orbita Hyperspectral
Gong Cheng, Xingwang Zhou, Meiqing Ding, Buqing Wang, Lingyi Liao   +4 more
doaj   +1 more source