Results 71 to 80 of about 361,441 (286)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Traffic fatalities prediction based on support vector machine [PDF]

Archives of Transport, 2016
To effectively predict traffic fatalities and promote the friendly development of transportation, a prediction model of traffic fatalities is established based on support vector machine (SVM).
Ting Li, Yunong Yang, Yonghui Wang, Chao Chen, Jinbao Yao   +4 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Air quality impact of a decision support system for reducing pollutant emissions: CARBOTRAF [PDF]

, 2014
Traffic congestion with frequent “stop & go” situations causes substantial pollutant emissions. Black carbon (BC) is a good indicator of combustion-related air pollution and results in negative health effects.
Assamer, J, Beckx, C, Breuss, S, Dahlem, D, Heilmann, B, Hu, J, Kolbl, R, Kouwijzer, G, Lefebvre, W, Lenz, G, Litzenberger, M, Marcinek, M, Mascia, M, Mills, J, North, R, Ritchter, G, Theunis, J, van Poppel, M, Vranckx, S   +18 more
core  

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

A structured distributed learning framework for irregular cellular spatial-temporal traffic prediction

Digital Communications and Networks
Spatial-temporal traffic prediction technology is crucial for network planning, resource allocation optimizing, and user experience improving. With the development of virtual network operators, multi-operator collaborations, and edge computing, spatial ...
Xiangyu Chen, Kaisa Zhang, Gang Chuai, Weidong Gao, Xuewen Liu, Yibo Zhang, Yijian Hou   +6 more
doaj   +1 more source

Hybrid traffic prediction scheme for intelligent transportation systems based on historical and real-time data

International Journal of Distributed Sensor Networks, 2017
Traffic prediction in smart cities is an essential way for intelligent transportation system. The objective of this article is designing and implementing a traffic prediction scheme which can forecast the traffic flow with high efficiency and accuracy in
Jiaming Xie, Yi-King Choi
doaj   +1 more source

Traffic prediction with embeddings

, 2023
Forecasting traffic flow is a critical task in transportation and community transport. It involves predicting traffic speed in a road network using historical data. To do this, sensors measure and record the traffic speed on the chosen roads. However, this task is challenging because the sensors’ dependencies cannot be explained only by their relative ...
openaire   +2 more sources

Epilepsy‐Associated Variants of a Single SCN1A Codon Exhibit Divergent Functional Properties

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Pathogenic variants in SCN1A, which encodes the voltage‐gated sodium channel NaV1.1, are associated with multiple epilepsy syndromes exhibiting a range of clinical severity. SCN1A variants are reported in different syndromes, including Dravet syndrome, which is associated with loss‐of‐function, whereas neonatal/infantile‐onset ...
Lanie N. Liebovitz, Christopher H. Thompson, Linda C. Laux, Alfred L. George Jr.   +3 more
wiley   +1 more source