Results 251 to 260 of about 4,055,099 (393)

Dose Selection for DuoBody®‐CD40x4‐1BB (GEN1042/BNT312) Using a mPBPK/RO Model Leveraging Preclinical and Clinical Data

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
Optimizing target engagement for bispecific antibodies (bsAbs) is challenging, as bsAbs bind to two different targets in vivo to form a trimolecular complex (trimer), and likely display a bell‐shaped concentration–response curve. bsAbs trimer formation is expected to be related to efficacy and safety, and determining the dose level at which it is ...
Gaurav Bajaj   +16 more
wiley   +1 more source

Traffic safety culture of professional drivers in the State of Qatar

open access: yesIATSS Research, 2019
C. Timmermans   +4 more
semanticscholar   +1 more source

Bridging THC Knowledge Gaps for Safer Roads: A Call for Action

open access: yesClinical Pharmacology &Therapeutics, EarlyView.
The rising cases of cannabis‐impaired driving present a looming public safety concern that's currently addressed through varying state regulations. However, these regulations are yet validated and lack scientific robustness. One of the roadblocking factors is our insufficient understanding of THC's pharmacokinetics (PK) and pharmacodynamics (PD) due to
Peizhi Li, Guohua An
wiley   +1 more source

AI and the Future of Disputing: Naming, Blaming, Claiming, and Preventing

open access: yesConflict Resolution Quarterly, EarlyView.
ABSTRACT This paper explores the transformative impact of artificial intelligence (AI) on dispute resolution mechanisms. Our analysis builds on the longstanding framework for explaining the stages through which disputes evolve: the “naming, blaming, claiming” model by Felstiner, Abel, and Sarat (1981).
Ethan Katsh   +2 more
wiley   +1 more source

A Nonessential Corporate Social Responsibility Reorientation: The Woke‐Washing Phenomenon in Victoria's Secret's Transformation

open access: yesCorporate Social Responsibility and Environmental Management, EarlyView.
ABSTRACT In markets that prioritize Corporate Social Responsibility, brands frequently encounter pressure to adopt socially progressive values. Victoria's Secret's recent shift toward inclusivity exemplifies how rapid moral repositioning can elicit skepticism and accusations of “woke‐washing.” Despite extensive research on brand authenticity, consumer ...
Angela Lizzi   +2 more
wiley   +1 more source

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