Results 161 to 170 of about 7,361 (251)

Rapid and Direct Detection of Methamphetamine in Biofluids using a MXene‐Enabled Electrochemical Sensor

Advanced Science, EarlyView.
A MXene‐enhanced electrochemical sensor enables the rapid and direct detection of methamphetamine. Molecular simulations reveal that specific MXene surface functional groups act as key signal amplifiers by facilitating interfacial interactions. The sensor demonstrates high sensitivity and robust performance in complex biological matrices.
Ri Wang, Xiaofei Deng, Bo Chen, Jienan Shen, Wei Xu, Yingjie Zhu, Yi Zhang, Hui Yang   +7 more
wiley   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

Dynamic Shifts in ER–Plasma Membrane Junctions Signaling Define Pro‐Metastatic N‐Glycosylation and Predict Prostate Cancer Progression

Advanced Science, EarlyView.
Prostate cancer remains a leading cause of male cancer death, yet screening cannot reliably identify aggressive disease, underscoring the need for tissue biomarkers. It is shown that primary tumors increase ER–plasma membrane junction signaling via STIM1/ORP5, whereas metastasis features their loss, Golgi dispersal, and rapid conversion of high‐mannose
Amanda J. Macke, Tania Kamal, Taylor E. Divita, Artem N. Pachikov, Chad A. LaGrange, Rajesh Ravichandran, Martha Morton, Robert Powers, Haowen Qiu, Jean‐Jack M. Riethoven, Colm Morrissey, Melinda Wojtkiewicz, Rebekah L. Gundry, Carol A. Casey, Armen Petrosyan   +14 more
wiley   +1 more source

Albumin‐Bound STING Agonist Reprograms HSPCs to Antitumor Neutrophils Enhancing CD8+ T Cell Immunity

Advanced Science, EarlyView.
This study demonstrates that an albumin‐bound STING agonist (Nano ZSA‐51D) reprograms HSPCs to produce antitumor neutrophils with enhanced MHC I–mediated CD8+ T cell activation, thereby sensitizing tumors to α‐PD1 therapy. These findings highlight a strategy to target early hematopoiesis for shaping neutrophil fate and potentiating cancer immunotherapy.
Jinsong Tao, Hong‐Yi Zhao, Chengyi Li, Hanning Wen, Fang Ke, Qiuxia Li, Miao He, Bo Wen, Zhongwei Liu, Kai Sun, Wei Gao, Duxin Sun   +11 more
wiley   +1 more source

Light‐Harvesting Photothermal Hotspots Enabled by NIR Scattering‐Absorption Coupling

Advanced Science, EarlyView.
By coupling the broadband scattering of nanodiamonds with the plasmonic absorption of gold nanostars, this work proposes a novel strategy for the active modulation of photon transport. This strategy creates localized photothermal hotspots in turbid media and achieves a supra‐additive heating efficiency, thereby providing a universal platform for low ...
Zebin Wu, Changming Bao, Pengyu Zhang, Tao Ding, Weiming Lin, Haodong Li, Wenjian Luo, Xizhi Deng, Hao Wang, Guanle Li, Hongyue Hu, Ye Wang, Dawei Jiang, Yu Zhang, Sisi Jia, Nan Zhang, Min Ke, Le Liang   +17 more
wiley   +1 more source

Thermally Programmable Two‐Port Non‐Hermitian Acoustic Metastructure for Broadband and Direction‐Dependent Absorption

Advanced Science, EarlyView.
A thermally programmable two‐port non‐Hermitian acoustic metastructure is presented, where temperature acts as a non‐geometric tuning variable. Thermal modulation reconfigures impedance matching and loss‐leakage coupling, enabling exceptional‐point driven, broadband, and direction‐dependent sound absorption without requiring geometric reconfiguration ...
Zichao Guo, Zhendong Li, Ziping Lei, Zirui Yang, Kexin Zeng, Zheng Fan, Zhonggang Wang   +6 more
wiley   +1 more source

Complete vision-based traffic sign recognition supported by an I2V communication system. [PDF]

Sensors (Basel), 2012
García-Garrido MA, Ocaña M, Llorca DF, Arroyo E, Pozuelo J, Gavilán M.   +5 more
europepmc   +1 more source

PAIR: Reconstructing Single‐Cell Open‐Chromatin Landscapes for Transcription Factor Regulome Mapping

Advanced Science, EarlyView.
scATAC‐seq analysis is often constrained by limited sequencing depth, extreme sparsity, and pervasive technical missingness. PAIR is a probabilistic framework that restores scATAC‐seq accessibility profiles by directly modeling the native cell–peak bipartite structure of chromatin accessibility.
Yanchi Su, Qi Qi, Yi Fan, Yubo Wang, Gaoyang Hao, Ka‐Chun Wong, Yunhe Wang, Xiangtao Li   +7 more
wiley   +1 more source

Tumor‐Induced Splenic Remodeling: Mechanisms of Systemic Immunosuppression and Emerging Therapeutic Opportunities

Advanced Science, EarlyView.
ABSTRACT Despite the transformative impact of cancer immunotherapies such as immune checkpoint blockade, durable clinical responses remain limited. Increasing evidence indicates that antitumor immunity is governed not only by the tumor microenvironment, but also by systemic immune regulation mediated by peripheral immune organs. Among these, the spleen
Yuehua Liu, Xiaoqian Nie, Xiaofei Gao
wiley   +1 more source