Results 131 to 140 of about 454,265 (301)

Postoperative Stress Accelerates Atherosclerosis Through Inflammatory Remodeling of the HDL Proteome and Impaired Reverse Cholesterol Transport

open access: yesAdvanced Science, EarlyView.
The study shows that noncardiac surgical inflammation rapidly disrupts HDL function and cholesterol efflux in mice and human patients. Impaired reverse cholesterol transport after surgery drives rapid lipid accumulation, NETosis, and apoptosis within atherosclerotic plaques.
Dominique M. Boucher   +15 more
wiley   +1 more source

Determining the effect of graphic elements of eight new traffic signs on conveying the message “Prohibition of using mobile phones while driving” [PDF]

open access: yesبهداشت و ایمنی کار
Introduction: The design of traffic signs should consider human cognitive abilities to enhance drivers’ understanding of the signs. Cognitive features, as one of the crucial principles of ergonomics, are among the influential factors in the design of ...
Aysa Ghasemi Koozekonan   +4 more
doaj  

Traffic Signs Recognition from Images [PDF]

open access: yes, 2019
Cílem této práce bylo nastudovat možnosti detekce a klasifikace objektů s využitím strojového učení a následně implementovat detektor pro dopravního značení v obrazech.
Bednář, Petr
core  

Genomics Insights Into High‐Latitude Adaptation of Tibetan Macaques

open access: yesAdvanced Science, EarlyView.
Tibetan macaques exhibit unique adaptations to cold, high‐latitude environments, including shortened tails and enhanced fat storage. Genomic analyses reveal a species‐specific TBX6 mutation linked to tail reduction and selection on lipid metabolism genes.
Rusong Zhang   +12 more
wiley   +1 more source

Aberrant SUMOylation Restricts the Targetable Cancer Immunopeptidome

open access: yesAdvanced Science, EarlyView.
Pharmacological SUMOylation inhibition (SUMOi) counteracts tumor immune evasion by unmasking an immunogenic HLA‐I peptide and neoepitope repertoire. By restoring HLA‐I ligand availability through increased antigen processing and presentation, enhanced proteasomal cleavage, and modulated TAP1 peptide affinity, SUMOi boosts tumor immunogenicity ...
Uta M. Demel   +19 more
wiley   +1 more source

Penerapan Metode Fuzzy untuk Game Keselamatan Pengendara Sepeda Motor Berbasis Android [PDF]

open access: yes, 2015
Safety of Motorcycle Rider had not noticed by people especially teenager who like speeding, illegal racing and violating traffic signs. These factors often the main cause of traffic accidents.Therefore an application is designed using fuzzy method for ...
Budianto, R. A. (Reo)
core  

PBRM1 Deficiency Reshapes an Immune Suppressive Microenvironment Through Epigenetic Tuning of PBRM1‐KDM5C‐IL6 Axis in ccRCC

open access: yesAdvanced Science, EarlyView.
PBRM1 ranks as the second most commonly mutated gene in ccRCC. This study reveals that PBRM1 loss promotes an immunosuppressive microenvironment by elevating M2 TAMs via the KDM5C–IL‐6 axis. These M2 TAMs, along with CAFs, form a barrier that excludes CD8+ T cells. Targeting IL‐6 synergizes with anti‐PD1 therapy, offering a promising strategy for PBRM1‐
Wenjiao Xia   +14 more
wiley   +1 more source

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